IQGAP3 Activators
IQGAP3 activators are not a homogenous group of compounds, but rather a diverse array of chemicals that can indirectly influence the regulatory role of IQGAP3 in cytoskeletal dynamics and cell proliferation. These compounds act on various signaling pathways and cellular processes that intersect with the functions of IQGAP3. For instance, PMA, by mimicking DAG, indirectly influences IQGAP3 through the PKC pathway, potentially affecting actin organization. In contrast, calpeptin's inhibition of calpains might stabilize cellular proteins that are important in the same pathways as IQGAP3, indirectly enhancing its stability and function.
Other chemicals, such as U73122 and Gö 6983, modulate phospholipase C and PKC activity, respectively, which are upstream of or parallel to the signaling pathways involving IQGAP3. This can lead to alterations in cytoskeletal organization and cell proliferation in which IQGAP3 is implicated. Compounds like jasplakinolide and blebbistatin exert their effects on actin dynamics and myosin II activity, thereby potentially affecting the cellular functions regulated by IQGAP3. Similarly, inhibitors of ROCK, MLCK, and the Arp2/3 complex, such as Y-27632, ML-7, and CK-666, respectively, indirectly influence the actin cytoskeleton, offering potential modulation of IQGAP3 activity. Forskolin's elevation of cAMP levels, lithium chloride's inhibition of GSK-3β, SB 203580's targeting of p38 MAPK, and LY294002's PI3K inhibition represent diverse mechanisms through which the activity of IQGAP3 might be indirectly modulated, reflecting the complexity of cellular signaling and the integrated nature of protein regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC) which is involved in various signaling pathways. PKC can phosphorylate numerous substrates that could intersect with the regulatory network of IQGAP3, potentially modulating its interaction with actin and contributing to its role in cytoskeletal organization. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
Calpeptin is a calpain inhibitor. By inhibiting calpains, it prevents the proteolytic cleavage of many proteins, which might stabilize proteins that interact with or regulate IQGAP3, potentially affecting its activity in cytoskeletal dynamics. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a potent and selective PKC inhibitor. By inhibiting PKC, it could prevent the phosphorylation of proteins involved in the same signaling pathways as IQGAP3, potentially modulating its activity in cell proliferation and cytoskeletal rearrangement. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide is an actin polymerization inducer. It stabilizes actin filaments and can lead to changes in cell morphology. By influencing actin dynamics, it could indirectly affect the role of IQGAP3 in actin filament organization and cell signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a specific inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Since ROCK is involved in actin cytoskeleton organization, inhibiting ROCK could lead to changes in IQGAP3-mediated signaling pathways that are important for cell shape and motility. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Blebbistatin is an inhibitor of myosin II ATPase activity. It impairs myosin II's contractile functions and is known to affect cell motility and cytokinesis. This could indirectly influence IQGAP3's role in cytoskeletal reorganization. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC 23766 is an inhibitor of the Rac1-GEF interaction. Rac1 is involved in actin polymerization and cell migration, and by inhibiting its activity, NSC 23766 could indirectly alter the cellular dynamics governed by IQGAP3. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, which controls actin polymerization. By inhibiting this complex, CK-666 could modulate actin filament assembly and potentially alter the dynamics of cellular structures that interact with or are regulated by IQGAP3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, increasing the levels of intracellular cyclic AMP (cAMP). Elevated cAMP activates PKA, which can phosphorylate various targets, potentially influencing the signaling networks to which IQGAP3 belongs, altering its regulatory impact on the cytoskeleton. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is known to inhibit GSK-3β, which is involved in a multitude of signaling pathways. By inhibiting GSK-3β, it could alter the phosphorylation state of proteins that interact with IQGAP3, potentially affecting its regulation of cytoskeletal dynamics. | ||||||