iPLA2γ Inhibitors
iPLA2γ inhibitors are chemicals that can impede the function of the enzyme known as calcium-independent phospholipase A2 gamma (iPLA2γ). iPLA2γ is a key player in lipid metabolism, regulating the hydrolysis of phospholipids in cell membranes. The inhibitors developed for targeting iPLA2γ are carefully synthesized compounds, often exhibiting a high degree of specificity for the enzyme.
Through their interaction with the active site of iPLA2γ, these inhibitors are capable of interrupting its catalytic activity, thereby affecting the liberation of fatty acids from cellular membranes. This inhibition holds potential implications for various cellular processes and signaling pathways that rely on the dynamic turnover of lipids. As such, iPLA2γ inhibitors have garnered significant interest in the realm of cellular research due to their capacity to unravel intricate mechanisms related to lipid biology and their impact on cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MAFP | 188404-10-6 | sc-203440 | 5 mg | $215.00 | 4 | |
Irreversible inhibitor that targets iPLA2γ by covalently modifying the active site serine residue, thus suppressing its phospholipase activity. | ||||||
ONO-RS-082 | 99754-06-0 | sc-201410 sc-201410A | 20 mg 100 mg | $81.00 $225.00 | ||
Selective iPLA2γ inhibitor that hinders enzymatic activity by interacting with the catalytic site, regulating intracellular lipid metabolism and inflammation. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
Peroxisome proliferator-activated receptor alpha (PPARα) agonist that indirectly affects iPLA2γ activity by altering gene expression related to lipid metabolism and inflammation. | ||||||