iPLA2γ Activators
iPLA2γ activators are chemical compounds known for their ability to modulate the activity of the enzyme calcium-independent phospholipase A2 gamma (iPLA2γ). This enzyme plays a crucial role in cellular lipid metabolism and membrane homeostasis. iPLA2γ activators are designed to interact with and enhance the enzymatic function of iPLA2γ, which is primarily responsible for the hydrolysis of glycerophospholipids. Glycerophospholipids are vital components of cellular membranes and serve as reservoirs of signaling molecules within the lipid bilayer. When activated, iPLA2γ cleaves these glycerophospholipids, releasing essential lipid mediators and signaling molecules that participate in various cellular processes.
The precise mechanisms through which iPLA2γ activators operate are still an area of ongoing research. However, these compounds are thought to enhance the catalytic activity of iPLA2γ by promoting its translocation to specific cellular membranes or by modifying its enzymatic properties. By doing so, iPLA2γ activators can influence lipid remodeling, alter the composition of cellular membranes, and generate lipid mediators that participate in intracellular signaling cascades. These processes are critical for various cellular functions, including membrane repair, inflammation, cell proliferation, and apoptosis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a natural substrate for iPLA2γ, activating the enzyme by serving as a substrate for lipid hydrolysis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates iPLA2γ by inhibiting the SERCA pump, leading to an increase in intracellular calcium levels, which can activate iPLA2γ. | ||||||
Triton X-100 | 9002-93-1 | sc-29112 sc-29112A | 100 ml 500 ml | $20.00 $42.00 | 55 | |
Triton X-100 is a non-ionic detergent that activates iPLA2γ by disrupting cellular membranes, increasing the availability of substrate lipids. | ||||||
N-Arachidonoyl glycine | 179113-91-8 | sc-362169 sc-362169A | 5 mg 25 mg | $114.00 $191.00 | 2 | |
NAGly is an endogenous lipid molecule that activates iPLA2γ, likely acting as an endocannabinoid signaling molecule. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB modulates intracellular calcium levels, indirectly activating iPLA2γ. The exact mechanisms involved are not fully elucidated. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a synthetic compound that activates PKC, which can phosphorylate and activate iPLA2γ, suggesting an indirect mechanism of activation. | ||||||