IP3R Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Paxilline | 57186-25-1 | sc-3588 sc-3588A | 5 mg 25 mg | $258.00 $942.00 | 14 | |
Paxilline is a potent inhibitor of inositol trisphosphate receptors (IP3Rs), disrupting calcium signaling pathways within cells. Its unique binding properties allow it to selectively target specific receptor subtypes, influencing the kinetics of calcium release from the endoplasmic reticulum. By altering the conformational dynamics of IP3Rs, Paxilline can modulate cellular responses to stimuli, thereby impacting various physiological processes and signaling cascades. | ||||||
SB 218078 | 135897-06-2 | sc-203692 | 1 mg | $136.00 | 1 | |
SB 218078 is a selective modulator of inositol trisphosphate receptors (IP3Rs), exhibiting unique interactions that enhance receptor sensitivity to inositol trisphosphate. This compound influences the allosteric regulation of IP3R, leading to altered calcium ion flux and distinct signaling outcomes. Its kinetic profile reveals a rapid onset of action, allowing for precise manipulation of intracellular calcium levels, which can significantly affect downstream cellular processes and pathways. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is a potent modulator of inositol trisphosphate receptors (IP3Rs), characterized by its ability to disrupt calcium signaling pathways. It acts as a competitive inhibitor, binding to the IP3R and altering its conformation, which affects calcium release from the endoplasmic reticulum. This compound exhibits unique kinetics, with a notable ability to rapidly desensitize the receptor, thereby fine-tuning cellular responses to various stimuli and influencing diverse physiological processes. | ||||||
Araguspongin B | 123000-02-2 | sc-205215 sc-205215A | 100 µg 250 µg | $490.00 $1170.00 | 1 | |
Araguspongin B is a selective modulator of inositol trisphosphate receptors (IP3Rs), distinguished by its unique binding affinity that stabilizes the receptor in a closed conformation. This interaction effectively inhibits calcium ion release from the endoplasmic reticulum, leading to altered intracellular calcium dynamics. Its distinct reaction kinetics allow for prolonged receptor modulation, impacting cellular signaling pathways and contributing to the regulation of various cellular functions. | ||||||