Integrin X Activators
Integrin X Activators encompass a variety of compounds that can influence the functional activity of Integrin X, a crucial protein in cell adhesion, migration, and signal transduction. Epigallocatechin gallate (EGCG) and RGD peptides directly bind to the extracellular domain of Integrin X, promoting the active conformation and increasing ligand affinity, leading to enhanced signaling. Manganese and calcium ions are critical for the structural maintenance of Integrin X, with Mn2+ ions particularly known for inducing the active conformation necessary for high-affinity ligand interactions. Such cation-mediated effects are essential for the proper functioning of Integrin X, as they support the transition to active states that are capable of initiating intracellular signaling cascades upon ligand engagement.
Tirofiban, despite its primary role as an antagonist, can modulate the activity of Integrin X through conformational changes or compensatory mechanisms, respectively, which result in enhanced function. Additionally, berberine and cilengitide may exert indirect effects on Integrin X through modulation of integrin signaling pathways, leading to improved binding efficiency and cellular responses. Phorbol 12-myristate 13-acetate (PMA) and lysophosphatidic acid (LPA) act through protein kinase C and RhoA/ROCK pathways, respectively, both of which contribute to the functional activation of Integrin X by influencing the phosphorylation states of associated proteins and cytoskeletal rearrangements. Forskolin raises cAMP levels, indirectly enhancing Integrin X activity through PKA-mediated signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) interacts with the extracellular domain of Integrin X, which may lead to the stabilization of the active conformation of the integrin, enhancing its binding to ligands and activation of associated signaling pathways. | ||||||
Manganese | 7439-96-5 | sc-250292 | 100 g | $270.00 | ||
Manganese ions can induce the activation of Integrins by promoting the adoption of an extended conformation of Integrin X, which is associated with high affinity for ligand binding and cellular signaling. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions are necessary for the proper conformation and function of Integrin X, maintaining its structure to effectively mediate cell adhesion and intracellular signaling upon ligand binding. | ||||||
Tirofiban-d6 | 144494-65-5 (unlabeled) | sc-475655 | 1 mg | $450.00 | ||
Tirofiban, though primarily an antagonist for certain integrins, can enhance the activity of Integrin X by causing a compensatory upregulation of its function when other integrin pathways are inhibited. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine can indirectly enhance Integrin X activity by interacting with proteins in the integrin-signaling pathway, facilitating the integrin's binding to its ligands and subsequent cellular responses. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Cilengitide targets integrins for inhibition but can indirectly enhance the activity of Integrin X by promoting integrin-mediated signaling through other pathways or integrin subtypes that interact with Integrin X. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can enhance the activity of Integrin X by phosphorylation of integrin-associated proteins, leading to increased integrin-ligand binding and signaling. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA interacts with its receptors to activate RhoA and downstream Rho-associated kinase (ROCK), which can lead to actin cytoskeleton rearrangement and influence Integrin X activation state. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which can lead to the activation of protein kinase A (PKA) and subsequently enhance the functional activity of Integrin X by altering integrin inside-out signaling. | ||||||