INSL4 Activators
INSL4 activators include a diverse range of compounds that can indirectly influence the expression or activity of INSL4. These substances would work through a variety of mechanisms, such as modulation of hormone receptors, alteration of gene transcription, and effects on signaling pathways relevant to placental development and function. Retinoic acid, for instance, might increase the production of INSL4 by activating RARs that bind to DNA and initiate transcription of genes involved in placental growth. Dexamethasone and hydrocortisone, through their action on glucocorticoid receptors, could similarly modulate gene expression, including potentially that of INSL4.
In addition, compounds like estradiol and leptin, through their roles in reproductive physiology, may upregulate INSL4 by influencing the hormones and factors involved in placental development. Forskolin, acting through cAMP and PKA, might enhance INSL4 expression by altering the activity of transcription factors. Insulin may also support the insulin/IGF axis, which is conducive to the activity of insulin-like growth factors, possibly including INSL4. Zinc sulfate, by enhancing the function of zinc finger transcription factors, and sodium butyrate, through changes in chromatin structure, both hold the potential to increase INSL4 transcription. Lastly, factors like resveratrol, EGF, and prolactin can create an environment that supports the production and action of INSL4 by impacting various pathways and cellular processes associated with placental biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression by activating nuclear retinoic acid receptors (RARs). Activation of RARs can lead to an upregulation of genes involved in placental development, which may indirectly increase the production or activity of INSL4. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that can regulate gene expression through the glucocorticoid receptor. It may affect the transcriptional regulation of genes involved in placental development and potentially enhance the expression of INSL4. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a primary estrogen, estradiol can modulate gene expression by engaging estrogen receptors. It plays a role in reproductive tissues and could upregulate the expression of INSL4 in the placenta. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels, forskolin activates PKA, which can phosphorylate transcription factors and alter gene expression. This cascade can potentially lead to increased expression of INSL4. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can stimulate the insulin/IGF axis and may lead to upregulation of related insulin-like factors, potentially including INSL4, by improving the overall insulin-like growth factor environment. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Leptin is involved in reproductive physiology and could affect the expression of various insulin-like factors. It may influence the production or release of INSL4 indirectly via its effects on energy balance and reproductive function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is crucial for the function of various DNA-binding proteins with zinc finger motifs, which can regulate gene transcription. An increased presence of zinc can potentially lead to enhanced transcription of genes, possibly including those for INSL4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This polyphenolic compound can modulate several signaling pathways, including sirtuins and AMP-activated protein kinase (AMPK), leading to altered gene expression patterns that may upregulate INSL4. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, butyrate can alter chromatin structure and thereby influence gene expression. It may increase the expression of genes involved in placental development and function, potentially including INSL4. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone, another glucocorticoid, can bind to glucocorticoid receptors and potentially enhance the expression of target genes, which might include INSL4 in placental tissue. | ||||||