INO80C Inhibitors

INO80C inhibitors predominantly focus on modulating the chromatin context or the DNA damage response, thereby indirectly influencing the activity and recruitment of the INO80 complex. Chemicals like Trichostatin A or SAHA that inhibit histone deacetylases lead to increased histone acetylation, altering the chromatin structure in a way that affects the ability of INO80C and its complex to bind or remodel chromatin. Similarly, agents like 5-aza-2'-deoxycytidine change the DNA methylation landscape, which can influence the recruitment of chromatin-associated proteins, including INO80C.

On the other hand, the DNA damage response is a critical aspect of INO80C's function. Compounds such as Olaparib and NU7441 target components of the DNA damage repair machinery. These chemicals might result in persistent DNA lesions or altered repair dynamics that can influence the recruitment and activity of chromatin remodelers, including the INO80 complex.