IMPACT Activators
IMPACT Activators are a set of chemical entities that augment the activity of IMPACT through a variety of specific cellular mechanisms. Forskolin, by raising cAMP levels, activates PKA, which may phosphorylate proteins in signaling pathways that IMPACT is involved in, thereby enhancing its functional activity. IBMX and Rolipram also lead to elevated cAMP levels, working synergistically with Forskolin to facilitate IMPACT activation through PKA signaling. Dibutyryl cAMP, being a cAMP analog, bypasses upstream activators and directly stimulates PKA, which is likely to enhance the activity of IMPACT in response to cellular stress. Compounds such as Epigallocatechin Gallate and Curcumin impact signaling pathways like those of AMPK and NF-κB, respectively, which could indirectly lead to the activation of IMPACT by modifying cellular stress responses and inflammatory pathways.
Additionally, Resveratrol's activation of SIRT1 can modulate deacetylation processes, potentially influencing stress response pathways and thus the activity of IMPACT. Spermidine, by promoting autophagy, may affect the functional role of IMPACT in dealing with cellular stress. Lithium Chloride, although primarily associated with the Wnt pathway, could indirectly affect IMPACT's role in signaling due to crosstalk between pathways. Sodium Butyrate changes gene expression patterns, which might indirectly enhance IMPACT activity by altering the expression of genes involved in stress response pathways. Metformin, known for activating AMPK, can have a similar effect on IMPACT by altering cellular metabolism and stress responses. Lastly, Nicotinamide Riboside elevates NAD+ levels, enhancing sirtuin activity, including SIRT1, which in turn might influence IMPACT's activity in longevity and stress response pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpenoid and activates adenylyl cyclase, which increases cyclic AMP (cAMP) in cells. Elevated cAMP levels can enhance the functional activity of IMPACT by promoting phosphorylation events through PKA, which may lead to its activation in cellular stress response pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in the cell. This accumulation can facilitate the activation of IMPACT through PKA-mediated phosphorylation pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), resulting in increased cAMP levels. cAMP acts as a second messenger, potentially enhancing the activity of IMPACT through cAMP-dependent protein kinase (PKA) signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that directly activates PKA. PKA can then phosphorylate substrates that may interact with or modify the activity of IMPACT, thus leading to its functional enhancement in various signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea with various biological effects. It has been known to modulate signaling pathways such as those involving AMP-activated protein kinase (AMPK), which could indirectly enhance the activity of IMPACT by modifying cellular energy balance and stress responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a biologically active polyphenolic compound found in turmeric, which can modulate multiple signaling pathways. It may influence the activity of IMPACT by altering inflammatory signaling pathways, such as NF-κB, which are known to respond to cellular stress and could cross-talk with pathways involving IMPACT. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a stilbenoid found in grapes and berries, which activates SIRT1, an NAD+-dependent deacetylase. Activation of SIRT1 is associated with cellular stress responses and could enhance the activity of IMPACT by modulating stress response pathways at the level of protein deacetylation. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a polyamine that has been shown to induce autophagy through inhibition of the acetyltransferase EP300. Induction of autophagy can influence IMPACT activity by altering the cellular response to stress and potentially enhancing its functional role in this process. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a glycogen synthase kinase 3 (GSK-3) inhibitor, which can lead to the activation of Wnt signaling pathway. Although not directly linked to IMPACT, enhanced Wnt signaling could indirectly affect pathways where IMPACT is functionally significant. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can alter chromatin structure and gene expression. By changing the expression of stress response genes, it may indirectly enhance the functional activity of IMPACT. | ||||||