IL1F6 Inhibitors
Chemical inhibitors of IL1F6 operate through various mechanisms to impede the protein's functional activity. Anakinra, for instance, directly competes with IL1F6 for its receptor, IL-1RI, on cell surfaces, effectively blocking the cytokine's ability to initiate intracellular signaling. Rilonacept, a fusion protein, acts as a decoy by binding IL1F6, sequestering it away from its natural receptor and thus preventing signal transduction. Similarly, Canakinumab, a monoclonal antibody, binds IL1F6 with high specificity, neutralizing its biological activity by precluding interaction with its receptor. Diacerein, through its metabolite rhein, interferes with the IL-1 signaling pathway, which suggests an indirect method of suppressing IL1F6's activity by inhibiting the activation of related cytokines in the IL-1 family.
Further along the signaling cascade, several compounds inhibit the pathways activated by IL1F6. Parthenolide and Bay 11-7082 both target the NF-κB pathway, a common downstream target of IL1F6. Parthenolide does so by preventing NF-κB from transcribing genes that contribute to the protein's inflammatory response. Bay 11-7082 impedes the phosphorylation and degradation of IκBα, thereby blocking NF-κB's activation by IL1F6 and subsequent pro-inflammatory gene expression. In a more indirect fashion, Tocilizumab, although primarily an IL-6 receptor inhibitor, can reduce the inflammatory response often potentiated by IL1F6 due to the overlapping functions of these cytokines. Methylene Blue, on the other hand, is proposed to limit IL1F6 activity by reducing the cytokine's release via the attenuation of oxidative stress and mitochondrial function. Spironolactone, known for its anti-inflammatory properties, can diminish the synthesis of various cytokines, thus likely reducing the availability of IL1F6. Lastly, Apremilast raises intracellular cAMP levels, which can dampen the expression of TNF-α and other cytokines, contributing to a cellular environment less conducive to IL1F6's activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $795.00 | ||
Anakinra is a recombinant human IL-1 receptor antagonist that blocks the biological activity of IL1F6 by competitively inhibiting its binding to the interleukin-1 type I receptor (IL-1RI), which is the signaling receptor for this cytokine. By preventing IL1F6 from binding to its receptor, anakinra directly inhibits the protein's function in mediating inflammation and immune responses. | ||||||
Diacerein | 13739-02-1 | sc-204717 sc-204717A | 50 mg 250 mg | $120.00 $544.00 | 2 | |
Diacerein is metabolized into rhein, which has been shown to inhibit the production of IL-1β, a cytokine closely related to IL1F6 in the IL-1 family. It inhibits the activation of IL-1β by interfering with the IL-1 signaling pathway. This suggests that diacerein could similarly inhibit the function of IL1F6 by impeding the same signaling pathway. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is a sesquiterpene lactone known to inhibit the nuclear factor kappa B (NF-κB) pathway, which is a signaling pathway that IL1F6 can activate. By inhibiting NF-κB, parthenolide indirectly inhibits the functional activity of IL1F6 by preventing the transcription of genes that are activated by this pathway and that contribute to the inflammatory response IL1F6 is involved in. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 is an inhibitor of NF-κB activation, which IL1F6 can induce. By blocking the phosphorylation and subsequent degradation of IκBα, Bay 11-7082 prevents the activation of NF-κB by IL1F6. This results in the inhibition of the expression of pro-inflammatory genes that are regulated by NF-κB and are part of the inflammatory response that IL1F6 participates in. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Methylene Blue has been shown to inhibit the release of pro-inflammatory cytokines, including IL-1 family members, by interfering with mitochondrial function and reducing oxidative stress. As IL1F6 is a member of the IL-1 family, Methylene Blue could indirectly inhibit the functional activity of IL1F6 by limiting its release from cells involved in the immune response. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone has anti-inflammatory effects and can inhibit the synthesis of pro-inflammatory cytokines. This suggests that spironolactone could inhibit the functional activity of IL1F6 by reducing the synthesis of this cytokine and similar inflammatory mediators. | ||||||
Apremilast | 608141-41-9 | sc-480062 | 5 mg | $444.00 | ||
Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that increases intracellular cAMP levels, leading to the inhibition of TNF-α and other inflammatory cytokines. By increasing cAMP, apremilast can indirectly inhibit the functional activity of IL1F6 by creating an anti-inflammatory environment and downregulating the signaling pathways in which IL1F6 is involved. | ||||||