Date published: 2026-4-12

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IL-6R Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of IL-6R monoclonal antibodies for various research applications. IL-6R Antibodies are optimized for techniques such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Interleukin-6 receptor (IL-6R) plays a crucial role in the immune response, inflammation, and hematopoiesis. IL-6R is involved in the signaling pathways that mediate the effects of interleukin-6, a cytokine that influences the differentiation of immune cells and the acute phase response. Dysregulation of IL-6R signaling has been implicated in various diseases, including autoimmune disorders and cancers, making it a significant target for therapeutic intervention. Researchers worldwide utilize IL-6R monoclonal antibodies to explore cellular mechanisms and pathways related to immune system function. Understanding IL-6R's molecular interactions and signaling cascades can lead to improved therapeutic strategies for inflammatory conditions. IL-6R monoclonal antibodies enable detailed investigation of receptor expression patterns across different cell types and tissues. Santa Cruz Biotechnology monoclonal antibodies support researchers in advancing scientific knowledge and developing potential therapeutic approaches for IL-6R-related diseases.

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IL-6R Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

IL-6Rα Antibody (D-8)

sc-374259mouse IgG1 κ433-460 (m)WB, IP, IF, ELISAm, r
14
(5)

IL-6Rα Antibody (H-7)

sc-373708mouse IgG1 κ441-468 (h)WB, IP, IF, IHC(P), ELISAm, r, h
28
(8)

IL-6Rα Antibody (2B2.3)

sc-71366mouse IgG1(h)FCM
1
(1)

IL-6R CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IL-6Rα CRISPR/Cas9 KO Plasmid (h2)

sc-400582-KO-2hGene KnockoutGFP0
(0)

IL-6Rα HDR Plasmid (h2)

sc-400582-HDR-2hHomology Directed RepairPuromycin0
(0)

IL-6Rα Double Nickase Plasmid (h)

sc-400582-NIChGene KnockoutPuromycin0
(0)

IL-6Rα Double Nickase Plasmid (h2)

sc-400582-NIC-2hGene KnockoutPuromycin0
(0)

IL-6Rα CRISPR/Cas9 KO Plasmid (m)

sc-421115mGene KnockoutGFP0
(0)

IL-6Rα HDR Plasmid (m)

sc-421115-HDRmHomology Directed RepairPuromycin0
(0)

IL-6R CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IL-6Rα CRISPR Activation Plasmid (h)

sc-400582-ACThGene ActivationPuro, Blast, Hygro0
(0)

IL-6Rα CRISPR Activation Plasmid (h2)

sc-400582-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

IL-6R siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IL-6Rα siRNA (h)

sc-35663hGene SilencingN/A
5
(0)

IL-6Rα shRNA Plasmid (h)

sc-35663-SHhGene SilencingPuromycin
5
(0)

IL-6Rα shRNA (h) Lentiviral Particles

sc-35663-VhGene SilencingPuromycin
5
(0)

IL-6Rα siRNA (m)

sc-40065mGene SilencingN/A
2
(0)

IL-6Rα shRNA Plasmid (m)

sc-40065-SHmGene SilencingPuromycin
2
(0)

IL-6Rα shRNA (m) Lentiviral Particles

sc-40065-VmGene SilencingPuromycin
2
(0)