IL-33 Inhibitors
IL-33 inhibitors belong to a class of chemical compounds designed to target and interfere with the activity of Interleukin-33 (IL-33), a cytokine that plays a crucial role in immune and inflammatory responses within the body. IL-33 is a member of the IL-1 family and is produced by various cell types, particularly in response to tissue damage or inflammation. It acts as an alarmin, a molecule released by damaged cells to signal the immune system and initiate a response. IL-33 binds to its receptor, ST2, which is expressed on various immune cells, leading to the activation of signaling pathways that can contribute to immune reactions and inflammation. IL-33 is involved in the regulation of immune cell recruitment, cytokine production, and tissue repair processes. IL-33 inhibitors are designed to modulate or block these interactions between IL-33 and its receptor, potentially influencing the downstream immune responses and inflammatory cascades.
The development of IL-33 inhibitors is driven by the need to better understand the complex immune processes and inflammatory conditions in which IL-33 is implicated. By targeting IL-33, these inhibitors offer researchers a valuable tool for investigating the specific roles of IL-33 in various physiological and pathological contexts. They can provide insights into the intricate signaling pathways that govern immune responses and may have implications for conditions characterized by excessive inflammation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits IL-33 expression by blocking NF-κB activation and reducing inflammatory responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may inhibit IL-33 via downregulation of pro-inflammatory cytokines, limiting its release. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin suppresses IL-33 by interfering with NF-κB signaling and modulating immune responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane hinders IL-33 production through its anti-inflammatory and antioxidant properties. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein inhibits IL-33 expression by interfering with MAPK pathways, reducing cytokine release. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG may suppress IL-33 via modulation of NF-κB, curbing the inflammatory response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein can inhibit IL-33 expression by disrupting JAK/STAT signaling and cytokine release. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine may inhibit IL-33 by reducing NF-κB activation, thus dampening the inflammatory process. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin suppresses IL-33 through inhibition of the NF-κB pathway and modulation of immune responses. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin may inhibit IL-33 expression by interfering with JNK pathways and reducing cytokine production. | ||||||