nterleukin-26 (IL-26) inhibitors represent a novel class of chemical compounds designed to modulate the activity of interleukin-26, a member of the IL-10 cytokine family. IL-26, initially identified for its role in immune responses, particularly during inflammatory processes, is produced by various immune cells, including T cells and monocytes. The chemical entities categorized as IL-26 inhibitors are specifically engineered to interfere with the signaling pathways associated with IL-26, thereby exerting a regulatory influence on its biological functions. These inhibitors typically act at the molecular level, disrupting the binding interactions between IL-26 and its cognate receptors on target cells. By obstructing this interaction, IL-26 inhibitors aim to attenuate the downstream cascades triggered by IL-26, ultimately modulating the immune responses orchestrated by this cytokine.
IL-26 inhibitors represents a significant advancement in the field of immunopharmacology, offering potential avenues for fine-tuning immune responses in various pathological conditions. The intricate interplay between IL-26 and its associated signaling pathways makes these inhibitors promising candidates for elucidating the underlying mechanisms of immune regulation. Researchers are actively exploring the structural features and mechanisms of action of IL-26 inhibitors to refine their design and enhance their specificity. The ongoing investigations into the precise ways these inhibitors interfere with IL-26 function contribute to a deeper understanding of the intricate immune network and may pave the way for the development of targeted interventions in conditions where IL-26 plays a pivotal role in modulating immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $156.00 $339.00 | 59 | |
Inhibits Janus kinases (JAKs), which are involved in the signaling pathway leading to the production of IL-26. By blocking JAKs, this compound can reduce IL-26 expression as it is downstream of the JAK/STAT signaling pathway. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
Targets STAT3, a transcription factor activated by JAKs that can induce IL-26 expression. Inhibiting STAT3 can diminish IL-26 production in cells where STAT3 is the upstream activator. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibits NF-κB activation, which can regulate IL-26 expression. By preventing NF-κB from translocating to the nucleus, it may downregulate IL-26 production. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
Another inhibitor of NF-κB, which may reduce expression levels of IL-26 indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, which may be involved in IL-26 expression. By inhibiting p38 MAPK, SB203580 can influence the production of IL-26. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK, which is upstream of ERK in MAPK signaling. ERK can influence IL-26 expression, so inhibition by PD98059 may reduce IL-26 levels. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, another MAPK that could be involved in regulating IL-26 expression. By blocking JNK, SP600125 may influence IL-26 production. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, which is part of a signaling pathway that could regulate IL-26 expression. By inhibiting PI3K, LY294002 may affect IL-26 levels. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor, which may indirectly influence IL-26 expression by modulating the PI3K/AKT pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, which can influence IL-26 expression through various signaling pathways. | ||||||