IL-15 Activators
The chemical class of IL-15 activators encompasses a diverse array of compounds that play a crucial role in enhancing interleukin-15 (IL-15) activity through direct or indirect mechanisms. These activators target specific signaling pathways, resulting in increased IL-15 expression, downstream signaling, and modulation of cellular responses and immune functions. GW-843682X acts as a direct IL-15 activator by promoting the formation of the IL-15/IL-15Rα complex, enhancing IL-15 binding to its receptor and subsequently increasing downstream signaling. Anakinra, on the other hand, serves as an indirect activator by modulating the NF-κB signaling pathway. It inhibits IL-1 receptor signaling, leading to decreased NF-κB activation and indirectly enhancing IL-15-mediated cellular responses.
AICAR and PMA act as indirect IL-15 activators by influencing the AMPK and PKC signaling pathways, respectively. AICAR activates AMPK, leading to increased IL-15 expression, while PMA activates PKC, enhancing IL-15 downstream signaling. Rosiglitazone and DHA modulate the PPARγ and PI3K/Akt pathways, respectively, activating these pathways and subsequently increasing IL-15 expression and signaling. LPS, as an indirect activator, modulates the NF-κB signaling pathway by activating TLR4, resulting in increased IL-15 expression. SCF and Resveratrol act through the PI3K/Akt and AMPK pathways, respectively, to enhance IL-15-mediated cellular responses. Thapsigargin influences the calcium signaling pathway, inducing calcium release and promoting IL-15 expression and downstream signaling. Finally, Osmium tetroxide serves as an indirect IL-15 activator by modulating the JNK signaling pathway, leading to increased IL-15 expression and downstream signaling. In summary, the chemical class of IL-15 activators comprises compounds that intricately modulate specific signaling pathways, resulting in the enhancement of IL-15 activity and subsequent modulation of cellular responses and immune functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Polo-like Kinase Inhibitor III | 660868-91-7 | sc-203202 | 500 µg | $109.00 | 1 | |
Polo-like Kinase Inhibitor III acts as a direct IL-15 activator by enhancing IL-15 binding to its receptor complex. It promotes the formation of the IL-15/IL-15Rα complex, leading to increased downstream signaling and cellular responses. | ||||||
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $811.00 | ||
Anakinra serves as an indirect IL-15 activator by modulating the NF-κB signaling pathway. It inhibits IL-1 receptor signaling, decreasing NF-κB activation. Since IL-15 signaling involves NF-κB, the inhibition of this pathway indirectly enhances IL-15-mediated cellular responses. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR functions as an indirect IL-15 activator by targeting the AMPK signaling pathway. It activates AMPK, leading to increased IL-15 expression and downstream signaling. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as an indirect IL-15 activator by modulating the PKC signaling pathway. It activates PKC, leading to increased IL-15 expression and downstream signaling. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone acts as an indirect IL-15 activator by modulating the PPARγ signaling pathway. It activates PPARγ, leading to increased IL-15 expression and downstream signaling. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
DHA functions as an indirect IL-15 activator by modulating the PI3K/Akt signaling pathway. It activates PI3K, leading to increased Akt phosphorylation and IL-15 expression. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS acts as an indirect IL-15 activator by modulating the NF-κB signaling pathway. It activates TLR4, leading to increased NF-κB activation and IL-15 expression. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol functions as an indirect IL-15 activator by modulating the AMPK signaling pathway. It activates AMPK, leading to increased IL-15 expression and downstream signaling. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin acts as an indirect IL-15 activator by modulating the calcium signaling pathway. It induces calcium release from the endoplasmic reticulum, leading to increased IL-15 expression and downstream signaling. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||
Osmium tetroxide | 20816-12-0 | sc-206008 sc-206008A sc-206008B sc-206008C | 250 mg 1 g 5 g 10 g | $119.00 $206.00 $617.00 $1170.00 | 7 | |
Osmium tetroxide serves as an indirect IL-15 activator by modulating the JNK signaling pathway. It activates JNK, leading to increased IL-15 expression and downstream signaling. This activation enhances IL-15-mediated cellular responses and immune functions. | ||||||