HYAL2 Inhibitors

The class of HYAL2 inhibitors would comprise molecules that can influence HYAL2 activity. This can happen through different mechanisms such as direct enzymatic inhibition, alteration of enzyme expression, or modulation of the enzyme's substrate availability. For example, glycyrrhizin and CAPE are known to have inhibitory effects on hyaluronidase activity, which could extend to HYAL2. Oleanolic acid and other natural compounds with anti-hyaluronidase activity might also reduce HYAL2 activity indirectly.

Agents that stabilize cells involved in inflammation, such as disodium cromoglycate, could decrease the release or activation of HYAL2. EDTA, as a metal chelator, could potentially affect HYAL2 if it is metal-dependent. Anthracyclines like daunorubicin affect DNA and might thereby influence HYAL2 expression. Methotrexate, by affecting folate metabolism, could indirectly influence glycosaminoglycan synthesis and thus the availability of HYAL2's substrate. Overall, the impact of these compounds on HYAL2 would arise from their broader effects on cellular metabolism and signaling rather than direct inhibition of the enzyme.