HscB Activators
HscB activators, as explored in this context, are chemically diverse compounds broadly connected by their influence on the [Fe-S] cluster assembly pathway, in which HscB plays a role. This group encompasses chemicals that either increase the demand for HscB's co-chaperone activity or increase the substrate availability for [Fe-S] cluster assembly. 2,2'-Dipyridyl, Bathophenanthroline, and Deferoxamine, for instance, are metal chelators that sequester iron, disrupting [Fe-S] cluster assembly and potentially increasing the demand for HscB's role.
On the other hand, Ferric citrate, Ferrous sulfate, Sodium sulfide, Sodium thiosulfate, L-Cysteine, and L-Methionine can all increase the substrate availability for [Fe-S] cluster assembly by providing bioavailable iron orsulfur, which are key components of [Fe-S] clusters. This could, in turn, increase the demand for HscB's co-chaperone activity. Lastly, Isopropyl β-D-1-thiogalactopyranoside (IPTG) functions as an inducer of protein expression, which could potentially increase the demand for HscB's co-chaperone activity by increasing the production of [Fe-S] cluster proteins. Sodium Molybdate and Sodium Tungstate, on the other hand, inhibit the activity of sulfite reductase, an enzyme involved in the biogenesis of [Fe-S] clusters, and could thus potentially increase the need for HscB's role. Therefore, these compounds collectively illustrate the intricate association between [Fe-S] cluster assembly and the indirect modulation of HscB.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Nitrobiphenyl | 92-93-3 | sc-216963 | 10 mg | $300.00 | ||
Bathophenanthroline is another iron chelator, and its activity could similarly increase the demand for HscB's co-chaperone activity by disrupting [Fe-S] cluster assembly. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1039.00 $2866.00 $4306.00 $8170.00 | 19 | |
Deferoxamine is a pharmaceutical iron chelator that could also increase the demand for HscB's role in [Fe-S] cluster assembly by sequestering iron. | ||||||
Iron(III) citrate | 3522-50-7 | sc-286019 sc-286019A | 100 g 250 g | $45.00 $85.00 | ||
Ferric citrate is a source of bioavailable iron, which could increase the substrate availability for [Fe-S] cluster assembly and thus potentially increase the demand for HscB's co-chaperone activity. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $72.00 $107.00 | ||
Ferrous sulfate is another source of bioavailable iron, with similar potential effects on HscB activity as ferric citrate. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $50.00 $110.00 $440.00 $1128.00 $2135.00 | 1 | |
L-Cysteine is a source of bioavailable sulfur in the form of a common amino acid, potentially increasing the substrate availability for [Fe-S] cluster assembly and HscB's co-chaperone activity. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
L-Methionine is another amino acid source of bioavailable sulfur, with similar potential effects on HscB activity as L-cysteine. | ||||||
IPTG, Dioxane-Free | 367-93-1 | sc-202185 sc-202185A sc-202185B sc-202185C sc-202185D sc-202185E sc-202185F | 1 g 5 g 100 g 500 g 1 kg 10 kg 25 kg | $50.00 $115.00 $500.00 $1750.00 $2000.00 $16320.00 $32130.00 | 27 | |
IPTG is a common inducer of protein expression in bacteria and could possibly increase the demand for HscB's co-chaperone activity by increasing the production of [Fe-S] cluster proteins. | ||||||
Sodium molybdate | 7631-95-0 | sc-236912 sc-236912A sc-236912B | 5 g 100 g 500 g | $55.00 $82.00 $316.00 | 1 | |
Sodium molybdate inhibits the activity of sulfite reductase, an enzyme involved in the biogenesis of iron-sulfur clusters, potentially increasing the demand for HscB's co-chaperone activity. | ||||||