HRF Activators
HRF, an essential player in actin cytoskeleton dynamics, can be modulated by a spectrum of chemical activators. NSC23766, a Rac1 inhibitor, indirectly activates HRF by inhibiting Rac1 activity. Reduced Rac1 activity influences downstream signaling cascades, leading to enhanced HRF expression and its involvement in actin cytoskeleton dynamics. Y-27632, a ROCK inhibitor, indirectly influences HRF by modulating Rho/ROCK signaling. Inhibition of ROCK alters cytoskeletal dynamics and downstream signaling, impacting HRF expression and its role in actin cytoskeleton regulation. Latrunculin A, an actin polymerization inhibitor, indirectly activates HRF by disrupting actin dynamics. Disruption of actin polymerization influences downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton modulation. CK-666 and CK-548, Arp2/3 complex inhibitors, indirectly influence HRF by inhibiting actin nucleation. Inhibition of the Arp2/3 complex alters actin polymerization dynamics, impacting downstream signaling and leading to enhanced HRF expression and its role in actin cytoskeleton regulation. Jasplakinolide, an actin stabilizer, indirectly activates HRF by stabilizing actin filaments. Stabilization of actin filaments influences downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton modulation.
Blebbistatin, a myosin II inhibitor, indirectly influences HRF by modulating myosin II activity. Inhibition of myosin II alters actin-myosin dynamics, impacting downstream signaling and leading to enhanced HRF expression and its role in actin cytoskeleton regulation. SMIFH2, a formin inhibitor, indirectly activates HRF by modulating actin dynamics through formin inhibition. Altered actin dynamics influence downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton modulation. Cytochalasin D, an actin polymerization inhibitor, disrupts actin dynamics and indirectly activates HRF. Disruption of actin polymerization influences downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton regulation. This comprehensive array of HRF activators provides a foundation for further exploration into the intricate pathways and cellular processes that govern actin cytoskeleton dynamics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a ROCK (Rho-associated protein kinase) inhibitor, indirectly influences HRF by modulating Rho/ROCK signaling. Inhibition of ROCK alters cytoskeletal dynamics and downstream signaling, impacting HRF expression and its role in actin cytoskeleton regulation. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A, an actin polymerization inhibitor, indirectly activates HRF by disrupting actin dynamics. Disruption of actin polymerization influences downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton modulation. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666, an Arp2/3 complex inhibitor, indirectly influences HRF by inhibiting actin nucleation. Inhibition of the Arp2/3 complex alters actin polymerization dynamics, impacting downstream signaling and leading to enhanced HRF expression and its role in actin cytoskeleton regulation. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide, an actin stabilizer, indirectly activates HRF by stabilizing actin filaments. Stabilization of actin filaments influences downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton modulation. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin, a myosin II inhibitor, indirectly influences HRF by modulating myosin II activity. Inhibition of myosin II alters actin-myosin dynamics, impacting downstream signaling and leading to enhanced HRF expression and its role in actin cytoskeleton regulation. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2, a formin inhibitor, indirectly activates HRF by modulating actin dynamics through formin inhibition. Altered actin dynamics influence downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton modulation. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D, an actin polymerization inhibitor, indirectly activates HRF by disrupting actin dynamics. Disruption of actin polymerization influences downstream signaling pathways, leading to enhanced HRF expression and its involvement in actin cytoskeleton regulation. | ||||||