HoxC5 Inhibitors
HoxC5 inhibitors belong to a distinct chemical class characterized by their ability to modulate the activity of the HoxC5 gene. The HoxC5 gene is a member of the Hox gene family, which plays a crucial role in embryonic development and cellular differentiation. Hox genes encode transcription factors that regulate the spatial patterning and identity of cells during embryogenesis. Specifically, HoxC5 is involved in controlling the development of various tissues, including the nervous system and skeletal structures.
HoxC5 typically act by interfering with the normal functioning of this gene. They may operate at the transcriptional level, disrupting the binding of essential transcription factors or regulatory elements that govern HoxC5 expression. Alternatively, HoxC5 inhibitors could target post-transcriptional processes, such as mRNA stability or translation, to modulate the overall levels of the HoxC5 protein. The ultimate outcome of inhibiting HoxC5 is the alteration of cellular processes and developmental pathways governed by this gene, which can have downstream effects on tissue development and homeostasis.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits transcription factors and NF-κB pathway, potentially reducing the expression of HOXC5. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate can modulate several signaling pathways, possibly downregulating HOXC5 expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, which may affect chromatin remodeling and thus HOXC5 gene expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), potentially decreasing HOXC5 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a pleiotropic molecule that can modulate multiple signaling pathways, possibly leading to reduced HOXC5 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, also called Sirolimus, inhibits mTOR and can impact protein synthesis, potentially affecting HOXC5 levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol interacts with multiple signaling pathways, which may contribute to downregulation of HOXC5. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an ERK pathway inhibitor, which can have downstream effects on gene expression, including HOXC5. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, potentially affecting the activity of transcription factors controlling HOXC5 expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which can influence transcription factors and gene expression profiles, including HOXC5. | ||||||