Chemical activators of HoxC10 can influence the protein's activity by engaging with various cellular signaling pathways and modulating gene expression. Retinoic Acid, and its derivative ATRA, exert their effects by binding to retinoid receptors, which can lead to the transcriptional activation of target genes including HOXC10, particularly during processes involving cellular differentiation. β-estradiol and Dihydrotestosterone (DHT), through the estrogen and androgen receptors respectively, activate signaling pathways that can result in the increased transcription of genes such as HOXC10. Vitamin D3, upon binding to the vitamin D receptor, has a similar capability to influence gene expression profiles, potentially promoting the upregulation of HOXC10. T3, the active form of thyroid hormone, binds to thyroid hormone receptors and can lead to the transcriptional activation of target genes, including HOXC10.
Furthermore, epigenetic modifiers such as Sodium Butyrate and Trichostatin A, both histone deacetylase (HDAC) inhibitors, can lead to a more relaxed chromatin structure and subsequently increase the expression of genes like HOXC10. The demethylating agent 5-Azacytidine can reduce DNA methylation, which often results in the activation of gene expression. This mechanism also can be relevant to the action of Folic Acid, which contributes to one-carbon metabolism and thus may affect methylation patterns influencing HOXC10 expression. Genistein, by inhibiting tyrosine kinase activity, can activate cellular signaling pathways that upregulate gene expression, including that of HOXC10. Lastly, Resveratrol influences gene expression through the activation of sirtuin enzymes, which are known to affect chromatin structure and gene regulation, thus potentially leading to the increased expression of HOXC10. Each of these chemicals interacts with specific molecular pathways that are capable of upregulating the expression and consequent activity of HoxC10.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid regulates gene expression via retinoid receptors; can increase the expression of HOXC10 during cellular differentiation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-estradiol, through estrogen receptor-mediated signaling, can lead to the transcriptional activation of various genes, potentially including HOXC10. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 (Cholecalciferol) can modulate gene expression through the vitamin D receptor, potentially leading to the upregulation of HOXC10. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic Acid is involved in methylation processes; can contribute to epigenetic changes that may result in increased expression of HOXC10. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
T3 binds to thyroid hormone receptors affecting gene regulation; can potentially enhance expression of HOXC10. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, as an HDAC inhibitor, can cause hyperacetylation of histones, potentially leading to an increase in HOXC10 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can result in chromatin remodeling, potentially increasing expression of HOXC10. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein can act as a tyrosine kinase inhibitor, affecting cellular signaling pathways and possibly leading to the increased expression of HOXC10. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate sirtuin enzymes, influencing chromatin and gene expression, which may include the activation of HOXC10. | ||||||