HoxA4 Inhibitors
HoxA4 inhibitors are chemical compounds that modulate the activity of HoxA4, which is a member of the Hox gene family. Hox genes are transcription factors that play a pivotal role in embryonic development by regulating the spatial and temporal expression of genes involved in patterning and differentiation along the anterior-posterior axis. HoxA4, in particular, is implicated in the formation and identity of specific body structures during embryogenesis, as it participates in the regulation of genes responsible for organ and tissue development.
HoxA4 inhibitors exert their effects by interfering with the transcriptional activity of HoxA4, disrupting its role in gene regulation and embryonic development. This interference can lead to alterations in the expression of downstream target genes, influencing the developmental processes controlled by HoxA4. Researchers employ HoxA4 inhibitors as essential tools to investigate the specific roles of HoxA4 in various embryonic contexts and to gain a deeper understanding of the molecular mechanisms that underlie tissue and organ patterning during development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat inhibits histone deacetylases, leading to chromatin relaxation and potential downregulation of gene transcription, including HOXA4. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 is a G9a histone methyltransferase inhibitor, potentially resulting in altered histone methylation and HOXA4 expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that does not incorporate into DNA, possibly affecting methylation patterns of genes like HOXA4. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit DNA methyltransferases, which may lead to hypomethylation and altered gene expression patterns including HOXA4. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits NF-kB, a transcription factor that can regulate the expression of a wide range of genes, potentially including HOXA4. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, affects DNA repair and chromatin structure, which could have an impact on the expression of genes like HOXA4. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent histone deacetylase inhibitor, influencing chromatin remodeling and possibly affecting HOXA4 gene expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, affecting transcriptional elongation and potentially downregulating genes like HOXA4. | ||||||