Panobinostat (CAS 404950-80-7)

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別名: Panobinostat is also known as LBH-589.

アプリケーション： Panobinostat is a histone deacetylase (HDAC) inhibitor reported to inhibit human multiple myeloma cell lines.

CAS 番号: 404950-80-7

Purity: ≥98%

Molecular Weight: 349.43

Molecular Formula: C₂₁H₂₃N₃O₂

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* Refer to Certificate of Analysis for lot specific data (including water content).

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Western blot analysis of Ac-Histone H4 acetylation in untreated (A)...

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Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC₅₀ ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.

参考文献

1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695

2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412

3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321

4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036

Appearance :

Powder

Physical State :

Solid

Solubility :

Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).

保存方法 :

Store at -20° C

Melting Point :

>115° C (dec.)

Boiling Point :

608.15° C (Predicted)

Refractive Index :

n²⁰_D 1.68 (Predicted)

IC50 :

Histone deacetylase: IC₅₀ = 1.8 nM (Plasmodium falciparum); HDAC1: IC₅₀ = 6.8 nM (human); COLO 205: IC₅₀ = 18 nM (human); PC-3: IC₅₀ = 24 nM (human); A2780: IC₅₀ = 35 nM (human)

Ki Data :

HDAC4: K_i= 0.6 nM (human); HDAC2: K_i= 0.65 nM (human); HDAC6: K_i= 0.7 nM (human); HDAC5: K_i= 0.7 nM (human); HDAC1: K_i= 1 nM (human)

pK Values :

pK_a: 8.71 (Predicted), pK_b: 9.3 (Predicted)

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

RTECS :

UC6378000

PubChem CID :

6918837

MDL Number :

MFCD09833242

SMILES :

CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

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Panobinostat (CAS 404950-80-7) 参考文献

他の人がPanobinostat (CAS 404950-80-7)をどのように使用したかをご覧ください。エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 5 of 5 合計

PMID: # 30515817 Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.

PMID: # 29778644 Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 26379230 Franken, H. et al. 2015. Nat Protoc. 10: 1567-93.

PMID: # 32365976 Cancers (Basel). 12:

引用 1 to 5 of 5 合計

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