Panobinostat CAS: 404950-80-7
MF: C21H23N3O2
MW: 349.43

Panobinostat (CAS 404950-80-7)

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別名: Panobinostat is also known as LBH-589.
アプリケーション: Panobinostat is a histone deacetylase (HDAC) inhibitor reported to inhibit human multiple myeloma cell lines.
CAS 番号: 404950-80-7
Purity: ≥98%
Molecular Weight: 349.43
Molecular Formula: C21H23N3O2
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* Refer to Certificate of Analysis for lot specific data (including water content).

Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.


参考文献

1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695

2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412

3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321

4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
保存方法 :
Store at -20° C
Melting Point :
>115° C (dec.)
Boiling Point :
608.15° C (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Histone deacetylase: IC50 = 1.8 nM (Plasmodium falciparum); HDAC1: IC50 = 6.8 nM (human); COLO 205: IC50 = 18 nM (human); PC-3: IC50 = 24 nM (human); A2780: IC50 = 35 nM (human)
Ki Data :
HDAC4: Ki= 0.6 nM (human); HDAC2: Ki= 0.65 nM (human); HDAC6: Ki= 0.7 nM (human); HDAC5: Ki= 0.7 nM (human); HDAC1: Ki= 1 nM (human)
pK Values :
pKa: 8.71 (Predicted), pKb: 9.3 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
RTECS :
UC6378000
PubChem CID :
6918837
MDL Number :
MFCD09833242
SMILES :
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

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Panobinostat (CAS 404950-80-7)  参考文献

他の人がPanobinostat (CAS 404950-80-7)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 5 of 5 合計

PMID: # 30515817  Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.

PMID: # 31054975  Ali, I.|Ruiz, DG.|Ni, Z.|Johnson, JR.|Zhang, H.|Li, PC.|Khalid, MM.|Conrad, RJ.|Guo, X.|Min, J.|Greenblatt, J.|Jacobson, M.|Krogan, NJ.|Ott, M.| et al. 2019. Mol. Cell. 74: 1164-1174.e4.

PMID: # 29778644  Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 26379230  Franken, H. et al. 2015. Nat Protoc. 10: 1567-93.

PMID: # 32365976  Cancers (Basel). 12:

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