HORMAD2 Inhibitors
HORMAD2 Inhibitors represent a class of small molecules and compounds that have garnered significant attention in the field of molecular biology and cell biology research. These inhibitors are specifically designed to target and modulate the function of the HORMAD2 protein. HORMAD2, or Hormone-Regulated Nuclear Transport Factor 2, is a protein that plays a crucial role in the regulation of meiosis, a specialized cell division process that leads to the formation of gametes (sperm and eggs) in sexually reproducing organisms. During meiosis, HORMAD2 is involved in the control of homologous chromosome pairing and segregation, ensuring the faithful transmission of genetic material. HORMAD2 inhibitors, therefore, offer a valuable tool for investigating the intricacies of meiotic processes and studying the molecular mechanisms underlying genetic recombination and chromosomal stability.
The development and utilization of HORMAD2 inhibitors have provided researchers with the means to explore the intricate details of meiosis, allowing for a deeper understanding of the molecular events that govern this essential biological process. By selectively inhibiting HORMAD2 activity, these compounds can aid in elucidating the precise roles of HORMAD2 in meiotic chromosome dynamics, such as the regulation of DNA double-strand break repair and the assembly of the synaptonemal complex. This class of inhibitors has become invaluable in laboratory settings for advancing our knowledge of meiosis and its implications for genetic diversity, fertility, and reproductive health.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor that can disrupt cell cycle progression, which can indirectly affect HORMAD2 expression levels in cancer cells. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key kinase in cell growth and proliferation pathways, potentially decreasing HORMAD2 activity linked to these pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can alter chromatin structure and gene expression, potentially downregulating HORMAD2 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can modulate the PI3K/Akt pathway, potentially affecting HORMAD2-related signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that may interfere with stress-induced signaling pathways involving HORMAD2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that can block the MAPK/ERK pathway, potentially altering HORMAD2 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that may affect HORMAD2 activity through stress response and inflammatory signaling pathways. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can affect protein degradation pathways, thereby potentially influencing HORMAD2 stability. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 disrupts the interaction between p53 and MDM2, which may indirectly impact HORMAD2 expression in p53-regulated pathways. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide affects the degradation of transcription factors, which can indirectly affect HORMAD2 levels through altered gene expression. | ||||||