HOP-1 Activators
HOP-1 activators predominantly works indirectly due to the current lack of direct activators known for the protein HOP-1. HOP-1, being a part of the synaptonemal complex in the C. elegans model, is intrinsically associated with meiotic chromosome pairing and recombination. The chemicals in this class principally modulate signaling pathways and cellular processes that can influence the function and dynamics of the synaptonemal complex, and by extension, HOP-1.
For instance, chemicals like Dibutyryl-cAMP, IBMX, Cilostamide, and Rolipram elevate intracellular cAMP levels, thus modulating the cAMP/PKA pathway. The involvement of this pathway in meiotic processes suggests that influencing its activity can indirectly affect the assembly and function of the synaptonemal complex. Another subset, including 8-Br-cGMP, Sildenafil, Vinpocetine, YC-1, and BAY 41-2272, influence the levels of cyclic nucleotides (cAMP and cGMP), further suggesting their in affecting meiotic processes. Nitric oxide donors or modulators, such as L-NAME and SNAP, demonstrate the intricate roles of nitric oxide in meiotic processes, with its modulation possibly influencing the synaptonemal complex dynamics. The calcium ionophore, A23187, underscores the importance of calcium dynamics in cellular processes. Alterations in calcium concentrations can have downstream effects on several cellular events, including those associated with meiotic progression and the functionality of the synaptonemal complex. Collectively, these chemicals, while not directly activating HOP-1, showcase the interconnected cellular processes that can influence the dynamics and functionality of the protein.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
cAMP analog that can activate the cAMP/PKA pathway. In meiotic processes, PKA activation can influence the assembly and function of the synaptonemal complex, and therefore, potentially modulate the activity and function of HOP-1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Phosphodiesterase inhibitor that increases intracellular cAMP levels. By doing so, IBMX can indirectly influence the cAMP/PKA pathway, potentially leading to modulation of synaptonemal complex assembly and HOP-1 activity. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $102.00 $347.00 | 7 | |
cGMP analog that stimulates protein kinase G (PKG). Activation of PKG can affect various cellular processes, including meiotic progression, and indirectly influence the synaptonemal complex and its components, such as HOP-1. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Inhibitor of phosphodiesterase 3 (PDE3). By increasing cAMP levels, Cilostamide may influence meiotic events and indirectly modulate HOP-1 activity within the synaptonemal complex. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Specific PDE4 inhibitor, elevating cAMP levels. Elevated cAMP can affect the cAMP/PKA pathway, potentially influencing synaptonemal complex dynamics and indirectly modulating HOP-1. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
Nitric oxide synthase (NOS) inhibitor. NOS plays roles in meiotic processes, and its modulation can indirectly influence components of the synaptonemal complex, potentially affecting HOP-1 activity. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
Nitric oxide donor. NO can modulate various signaling pathways involved in meiotic processes. By doing so, SNAP can indirectly influence the synaptonemal complex and its constituent proteins, including HOP-1. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
PDE1 inhibitor, affecting cAMP and cGMP levels. By modulating these cyclic nucleotides, Vinpocetine can have indirect effects on meiotic processes, influencing the synaptonemal complex and potentially modulating HOP-1 activity. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $32.00 $122.00 $214.00 $928.00 | 9 | |
Stimulator of soluble guanylyl cyclase (sGC), increasing cGMP production. Elevated cGMP levels can influence meiotic events and the dynamics of the synaptonemal complex, potentially modulating HOP-1 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore that increases intracellular calcium levels. Changes in calcium dynamics can indirectly influence meiotic processes, potentially affecting the synaptonemal complex and the function of its components, like HOP-1. | ||||||