HOOK2 Activators

Hook microtubule-tethering protein 2 (HOOK2) is a crucial component of the cellular machinery, playing a significant role in the organization and function of the cytoskeleton. It belongs to the HOOK family of proteins, which are characterized by their involvement in microtubule-based processes and organelle positioning within cells.The primary function of HOOK2 is to mediate the positioning and tethering of organelles, particularly the centrosome and the Golgi apparatus. This is essential for maintaining proper cellular architecture and for ensuring accurate organelle distribution during cell division. HOOK2 achieves this by interacting with microtubules, the structural components of the cytoskeleton that facilitate transport within the cell and are integral to cell shape and division.

Structurally, HOOK2 is distinguished by the presence of a coiled-coil domain, which is typical of the HOOK protein family and is key to its function in organelle tethering. This domain facilitates the interaction of HOOK2 with other proteins and microtubules, enabling it to anchor organelles in specific cellular locations.Alterations in HOOK2 function or expression can have significant implications for cellular organization and function. Given its role in organelle positioning, changes in HOOK2 activity can disrupt cellular processes such as intracellular transport, cell signaling, and cell division. This makes HOOK2 a protein of interest in studies of cell biology and various diseases where cytoskeletal dysregulation is a factor.