Date published: 2026-7-15

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HMGCL Antibodies

Santa Cruz Biotechnology features a diverse variety of HMGCL monoclonal antibodies for research in biochemistry and molecular biology. HMGCL monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). HMGCL, or 3-hydroxy-3-methylglutaryl-CoA lyase, plays a crucial role in the metabolism of ketone bodies and amino acids, making it essential for energy production during fasting states. Its proper function is vital for maintaining metabolic homeostasis, and mutations in the HMGCL gene can lead to metabolic disorders such as HMG-CoA lyase deficiency. Understanding HMGCL function in cellular metabolism can provide insights into various physiological and pathological conditions. Researchers studying HMGCL can uncover new pathways and mechanisms involved in metabolic regulation. HMGCL research has significant implications for understanding metabolic disorders and developing potential therapeutic strategies. Investigating HMGCL expression patterns helps reveal its role in different tissues and developmental stages. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of metabolic processes and contribute to breakthrough discoveries in human health.

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HMGCL Antibodies

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HMGCL Antibody (63Z)

sc-100548mouse IgG2a κ1-326 (h)WB, IP, ELISAh
2
(2)

HMGCL siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

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HMGCL siRNA (h)

sc-78794hGene SilencingN/A0
(0)

HMGCL shRNA Plasmid (h)

sc-78794-SHhGene SilencingPuromycin0
(0)

HMGCL shRNA (h) Lentiviral Particles

sc-78794-VhGene SilencingPuromycin0
(0)

HMGCL siRNA (m)

sc-146051mGene SilencingN/A
1
(0)

HMGCL shRNA Plasmid (m)

sc-146051-SHmGene SilencingPuromycin
1
(0)

HMGCL shRNA (m) Lentiviral Particles

sc-146051-VmGene SilencingPuromycin
1
(0)

HMGCL CRISPR Knockout (KO) and HDR Plasmids

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HMGCL CRISPR/Cas9 KO Plasmid (h)

sc-403841Gene Knockouth0
(0)

HMGCL HDR Plasmid (h)

sc-403841-HDRHomology Directed Repairh0
(0)

HMGCL CRISPR/Cas9 KO Plasmid (m)

sc-420876Gene Knockoutm0
(0)

HMGCL HDR Plasmid (m)

sc-420876-HDRHomology Directed Repairm0
(0)

HMGCL CRISPR Double Nickase Plasmids

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HMGCL Double Nickase Plasmid (h)

sc-403841-NICGene Knockouth0
(0)

HMGCL Double Nickase Plasmid (h2)

sc-403841-NIC-2Gene Knockouth0
(0)

HMGCL CRISPR Activation Plasmids and Lentiviral Particles

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HMGCL CRISPR Activation Plasmid (h)

sc-403841-ACTGene Activationh0
(0)