HMG-14 Inhibitors
HMG-14 inhibitors are chemical compounds that modulate the activity of HMG-14, also known as high-mobility group protein 14. HMG-14 is a nuclear protein with a high mobility in electrophoretic gels, and it belongs to the high-mobility group (HMG) family of proteins, which are involved in various aspects of chromatin structure and function. HMG-14, in particular, plays a critical role in regulating the architecture and dynamics of chromatin, the complex DNA-protein structure within the cell nucleus.
HMG-14 inhibitors exert their effects by interfering with the binding and functional interactions of HMG-14 with chromatin, histones, and other chromatin-associated proteins. This interference can lead to alterations in chromatin structure, DNA accessibility, and gene expression patterns, ultimately influencing the transcriptional landscape of the cell. Researchers employ HMG-14 inhibitors as essential tools to investigate the specific roles of HMG-14 in chromatin biology and to unravel the molecular mechanisms underlying chromatin remodeling and gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Sodium valproate is a histone deacetylase inhibitor that can alter gene expression, potentially reducing HMG-14 levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine intercalates into DNA and RNA, which can affect various cellular processes and potentially downregulate HMG-14 expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases, which may alter transcriptional regulation, potentially decreasing HMG-14 transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a histone deacetylase inhibitor; it can change gene expression patterns, possibly affecting HMG-14 levels. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
Rocaglamide inhibits translation by binding to the eIF4A component of the translation initiation complex, potentially reducing HMG-14 protein levels. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been shown to inhibit transcriptional activity, which may result in decreased expression of HMG-14. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that affects the expression of genes by altering chromatin structure, potentially downregulating HMG-14. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, leading to effects on various cellular processes, including gene expression, which could lower HMG-14 levels. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit the proteasome and NF-kB pathway, potentially affecting the transcription of genes like HMG-14. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
PI-103 is a PI3K/mTOR inhibitor that can influence gene expression and protein synthesis, potentially affecting HMG-14 expression. | ||||||