Histone cluster 1 H4H Inhibitors
Histone cluster 1 H4H Inhibitors represent a specialized category of chemical compounds designed to selectively inhibit the activity of histone cluster 1, with a specific focus on the H4H subtype. Histones play a crucial role in the organization of DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H4H designation refers to a variant of histone H4, one of the core histones essential for nucleosome assembly. As a specific variant within histone cluster 1, H4H becomes a target for researchers seeking to unravel the complexities of chromatin dynamics and gene regulation.
The development of Histone cluster 1 H4H Inhibitors requires a comprehensive understanding of the structural characteristics of histone H4H and its specific role within chromatin organization. These inhibitors are intricately designed for specificity, aiming to selectively bind to key regions of Histone cluster 1 H4H and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H4H, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor that can cause DNA demethylation, potentially leading to altered gene expression profiles, which may include the expression of histone genes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is an HDAC inhibitor known to influence histone acetylation and can affect transcription of a wide range of genes, potentially including those for histones. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is an HDAC inhibitor that can change the acetylation state of histones, potentially influencing gene expression, which could include the expression of histone genes. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is an HDAC inhibitor that may affect chromatin structure and gene expression, potentially including the regulation of histone gene transcription. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
Chidamide is an HDAC inhibitor that can alter histone acetylation, potentially affecting gene expression, including histone genes. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
Givinostat is an HDAC inhibitor that can impact gene expression by altering histone and protein acetylation, which may include effects on histone gene expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is an HDAC inhibitor that can affect gene expression by changing the acetylation state of histones, potentially influencing the transcription of histone genes. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is an HDAC inhibitor that can modify the acetylation levels of histones, potentially affecting the expression of a wide array of genes, including histone genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can affect gene expression by altering histone acetylation, which may influence the transcription of histone genes. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
Sirtinol is an inhibitor of the sirtuin family of NAD+-dependent deacetylases, which can influence histone acetylation and gene expression, potentially affecting histone gene expression. | ||||||