Histone cluster 1 H3E Inhibitors
Histone cluster 1 H3E Inhibitors form a specialized category of chemical compounds designed to selectively hinder the activity of histone cluster 1, with a specific emphasis on the H3E subtype. Histones are fundamental proteins in the organization of DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H3E designation refers to a variant of histone H3, one of the core histones essential for nucleosome assembly. As a specific variant within histone cluster 1, H3E becomes a focal point for research aiming to unravel the intricacies of chromatin dynamics and gene regulation.
Developing Histone cluster 1 H3E Inhibitors requires a detailed understanding of the structural characteristics of histone H3E and its specific role within chromatin organization. These inhibitors are intricately engineered for specificity, aiming to selectively bind to key regions of Histone cluster 1 H3E and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H3E, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a DNA methyltransferase inhibitor. By reducing DNA methylation, it can alter gene expression patterns, potentially leading to reduced expression of certain histones. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It alters chromatin structure and can affect transcription factor accessibility, which might decrease histone gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can cause hyperacetylation of histones, affecting gene expression and potentially downregulating histone biosynthesis. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, another histone deacetylase inhibitor, can lead to changes in chromatin structure and gene expression, potentially affecting histone gene transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a potent inhibitor of histone deacetylases. By altering gene expression, it may play a role in decreasing the expression of histone proteins. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that may modify transcription and potentially reduce the expression of histones by altering the chromatin state. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
As a selective histone deacetylase inhibitor, entinostat can modulate gene expression which may include the downregulation of histone proteins. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a broad-spectrum histone deacetylase inhibitor that can affect a wide range of genes, potentially leading to a decrease in histone protein levels. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a selective histone deacetylase inhibitor that can influence gene expression and may result in the reduced expression of certain histones. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
As a DNA methyltransferase inhibitor, decitabine can alter methylation patterns and potentially impact histone protein expression by changing gene transcription. | ||||||