Histamine H4 Receptor Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thioperamide·maleate | 148440-81-7 | sc-201092 sc-201092A | 10 mg 50 mg | $100.00 $440.00 | ||
Thioperamide·maleate acts as a selective antagonist for the histamine H4 receptor, characterized by its unique ability to stabilize the receptor in an inactive conformation. This compound exhibits distinctive hydrophobic interactions that facilitate a strong binding affinity, impacting the receptor's conformational dynamics. Its kinetic profile reveals a slow dissociation rate, allowing prolonged modulation of receptor activity, which plays a crucial role in cellular signaling pathways. The compound's structural attributes enhance its specificity, influencing receptor-ligand interactions. | ||||||
JNJ 10191584 maleate | 869497-75-6 | sc-203613 sc-203613A | 10 mg 50 mg | $128.00 $536.00 | ||
JNJ 10191584 maleate is a selective antagonist of the histamine H4 receptor, notable for its unique binding mechanism that induces a conformational shift in the receptor. This compound engages in specific electrostatic interactions that enhance its affinity, while its steric properties contribute to a unique spatial orientation within the binding site. The compound's interaction kinetics reveal a gradual onset of action, allowing for sustained receptor modulation, which may influence downstream signaling cascades. | ||||||
A 943931 dihydrochloride | 1227675-50-4 | sc-291775 sc-291775A | 10 mg 50 mg | $205.00 $849.00 | ||
A 943931 dihydrochloride acts as a selective modulator of the histamine H4 receptor, characterized by its ability to form stable hydrogen bonds with key amino acid residues. This compound exhibits a distinct allosteric effect, altering receptor dynamics and enhancing ligand efficacy. Its unique solubility profile facilitates rapid diffusion across biological membranes, while its reaction kinetics suggest a reversible binding mechanism, allowing for fine-tuned regulation of receptor activity. | ||||||
VUF 8430 dihydrobromide | 100130-32-3 | sc-203719 sc-203719A | 5 mg 50 mg | $69.00 $559.00 | ||
VUF 8430 is a selective Histamine H4 Receptor antagonist. By directly inhibiting the H4 receptor, it interferes with histamine signaling and downstream pathways. This direct inhibition impacts cellular responses mediated by the H4 receptor, providing insights into the role of histamine in various physiological and pathological processes. | ||||||
JNJ7777120 | 459168-41-3 | sc-252930 | 5 mg | $121.00 | 1 | |
JNJ7777120 is a selective antagonist of the histamine H4 receptor, notable for its unique ability to engage in π-π stacking interactions with aromatic side chains within the receptor's binding pocket. This compound demonstrates a high affinity for the receptor, influencing downstream signaling pathways through modulation of G-protein coupling. Its lipophilic characteristics promote efficient membrane permeability, while its kinetic profile indicates a slow dissociation rate, contributing to prolonged receptor occupancy. | ||||||