Molecular structure of JNJ 10191584 maleate, CAS Number: 869497-75-6
JNJ 10191584 maleate (CAS 869497-75-6)
Alternate Names:
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate
Application:
JNJ 10191584 maleate is a selective histamine H4 receptor silent antagonist
CAS Number:
869497-75-6
Molecular Weight:
394.81
Molecular Formula:
C13H15ClN4O•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JNJ 10191584 maleate is a small molecule inhibitor that targets a specific enzyme involved in various cellular processes. It functions by binding to the active site of the enzyme, thereby preventing its normal function. This inhibition can lead to downstream effects on cell signaling, metabolism, and gene expression. JNJ 10191584 maleate is being studied for its potential role in modulating cellular pathways in various biological systems. Its mechanism of action makes it for investigating the function of the targeted enzyme and its impact on cellular physiology.
JNJ 10191584 maleate (CAS 869497-75-6) References
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- The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. | Dunford, PJ., et al. 2006. J Immunol. 176: 7062-70. PMID: 16709868
- The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. | Connelly, WM., et al. 2009. Br J Pharmacol. 157: 55-63. PMID: 19413571
- Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. | Desmadryl, G., et al. 2012. Br J Pharmacol. 167: 905-16. PMID: 22624822
- Pleiotropic effect of histamine H4 receptor modulation in the central nervous system. | Galeotti, N., et al. 2013. Neuropharmacology. 71: 141-7. PMID: 23583928
- Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes. | Vasicek, O., et al. 2014. Life Sci. 100: 67-72. PMID: 24530738
- Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration. | Kaneko, H., et al. 2014. Br J Pharmacol. 171: 3754-63. PMID: 24787705
- Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes. | Nosáľ, R., et al. 2015. Gen Physiol Biophys. 34: 209-16. PMID: 25730898
- Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. | Sanna, MD., et al. 2015. Pain. 156: 2492-2504. PMID: 26270581
- Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats. | Jochem, J., et al. 2016. J Physiol Pharmacol. 67: 67-74. PMID: 27010896
- Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress. | Sanna, MD., et al. 2017. Br J Pharmacol. 174: 28-40. PMID: 27714773
- Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. | Sanna, MD., et al. 2020. Eur J Pharmacol. 868: 172859. PMID: 31843515
- The Histamine H4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H3 Receptor Antagonist GSK189254. | Borgonetti, V. and Galeotti, N. 2022. Int J Mol Sci. 23: PMID: 36430790
Inhibitor of:
Histamine H4 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNJ 10191584 maleate, 10 mg | sc-203613 | 10 mg | $128.00 | |||
JNJ 10191584 maleate, 50 mg | sc-203613A | 50 mg | $536.00 |