HIRA Inhibitors
HIRA inhibitors belong to a chemical class that plays a pivotal role in the regulation of gene expression and chromatin structure within cells. HIRA, which stands for Histone Regulator A, is a key protein involved in histone deposition and nucleosome assembly, critical processes in the maintenance and modification of chromatin architecture. These inhibitors specifically target the activity of HIRA, disrupting its function and thereby influencing the dynamic organization of chromatin. To understand the significance of HIRA inhibitors, it is essential to delve into the molecular mechanisms they affect.
HIRA inhibitors work by interfering with the ability of HIRA to deposit histones onto DNA. Histones are proteins around which DNA is wound, forming the fundamental unit of chromatin, the nucleosome. HIRA normally facilitates the deposition of histones onto newly synthesized DNA, aiding in chromatin assembly and regulating gene expression. By inhibiting HIRA, these compounds disrupt the normal process of histone deposition, potentially leading to alterations in chromatin structure and gene regulation. This interference with chromatin dynamics can have far-reaching consequences for cellular processes, including transcription, DNA repair, and replication, ultimately influencing the functioning of the cell.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is a histone deacetylase inhibitor, which can indirectly affect HIRA's function in chromatin remodeling and histone deposition by altering the acetylation state of histones. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Similar to valproic acid, trichostatin A is a histone deacetylase inhibitor that can modulate chromatin structure and histone modification states, potentially influencing HIRA-mediated processes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
As a histone deacetylase inhibitor, SAHA can change the chromatin landscape, which may affect HIRA's role in the incorporation of the histone variant H3.3. | ||||||
M 344 | 251456-60-7 | sc-203124 sc-203124A | 1 mg 5 mg | $107.00 $316.00 | 8 | |
M344 is another histone deacetylase inhibitor that can lead to hyperacetylation of histones, potentially disrupting HIRA's function in chromatin dynamics. | ||||||
Splitomicin | 5690-03-9 | sc-358701 | 5 mg | $47.00 | ||
Splitomicin is a selective inhibitor of the sirtuin family of NAD+-dependent deacetylases, which can alter histone modification patterns and thereby affect HIRA's role. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid inhibits histone acetyltransferase activities, which could alter histone acetylation patterns and impact HIRA's interactions with chromatin. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $136.00 $492.00 | 13 | |
Garcinol is an inhibitor of histone acetyltransferases, which can affect histone acetylation states and potentially influence HIRA's function in chromatin remodeling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can inhibit histone deacetylase, leading to changes in the chromatin structure that may affect the activity of HIRA. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
BIX-01294 is a histone methyltransferase inhibitor, which can alter histone methylation patterns and potentially disrupt HIRA's chromatin-related activities. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor, which can influence DNA methylation status and subsequently affect HIRA's role in chromatin and epigenetic regulation. | ||||||