Molecular structure of Garcinol, CAS Number: 78824-30-3
Garcinol (CAS 78824-30-3)
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Alternate Names:
Garcinol is also known as Camboginol.
Application:
Garcinol is a polyisoprenylated benzophenone derived p300 and PCAF histone acetyltransferase inhibitor.
CAS Number:
78824-30-3
Purity:
≥95%
Molecular Weight:
602.80
Molecular Formula:
C38H50O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Garcinol (camboginol) is a polyisoprenylated benzophenone that can be found in the rind of Garcinia indica fruit and is a potent inhibitor of histone acetyltransferases p300 (IC50= ~7 µm) and PCAF (IC50= ~5 µm) in vitro. p300, also known as E1A binding protein p300, regulates cell growth and division through interacting with numerous transcription factors, and the p53 associated trancriptional coactivator PCAF (P300/CBP-associated factor) plays a direct role in transcriptional regulation. Reports show that Garcinol represses the p300-mediated acetylation of p53, promotes apoptosis through caspase-3 activation and predominantly down-regulates the global gene expression in HeLa cells. Researchers found that Garcinol exhibits dose-dependent cancer cell-specific growth inhibition in ER-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Additional research shows that Garcinol exhibits anti-carcinogenic and anti-inflammatory properties through selectively suppressing Prostaglandin E2 synthesis and 5-lipoxygenase product formation.
Garcinol (CAS 78824-30-3) References
- Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. | Matsumoto, K., et al. 2003. Biol Pharm Bull. 26: 569-71. PMID: 12673047
- Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. | Balasubramanyam, K., et al. 2004. J Biol Chem. 279: 33716-26. PMID: 15155757
- Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. | Mantelingu, K., et al. 2007. Chem Biol. 14: 645-57. PMID: 17584612
- Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. | Koeberle, A., et al. 2009. Biochem Pharmacol. 77: 1513-21. PMID: 19426689
- Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. | Ahmad, A., et al. 2010. J Cell Biochem. 109: 1134-41. PMID: 20108249
- Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. | Chen, CS., et al. 2011. Breast Cancer Res Treat. 125: 73-87. PMID: 20229177
- Garcinol suppresses RANKL-induced osteoclastogenesis and its underlying mechanism. | Jia, Y., et al. 2019. J Cell Physiol. 234: 7498-7509. PMID: 30471112
- Garcinol Suppresses IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-κB Signaling Pathway. | Jia, Y., et al. 2019. Inflammation. 42: 1754-1766. PMID: 31201586
- Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways. | Wang, J., et al. 2020. Acta Pharmacol Sin. 41: 82-92. PMID: 31371781
- Regulation of Garcinol on Histone Acetylation in the Amygdala and on the Reconsolidation of a Cocaine-Associated Memory. | Monsey, MS., et al. 2019. Front Behav Neurosci. 13: 281. PMID: 31998092
- Garcinol promotes hepatic gluconeogenesis by inhibiting P300/CBP-associated factor in late-pregnant sows. | Yao, W., et al. 2021. Br J Nutr. 126: 1-8. PMID: 32967737
- Garcinol Is an HDAC11 Inhibitor. | Son, SI., et al. 2020. ACS Chem Biol. 15: 2866-2871. PMID: 33034447
- Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest. | Zhang, M., et al. 2021. Oncol Rep. 45: 630-640. PMID: 33416149
- Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through α7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-κB Signaling Pathways. | Chang, NC., et al. 2021. Antioxidants (Basel). 10: PMID: 33809417
- Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H. | Corona, A., et al. 2021. Arch Pharm (Weinheim). 354: e2100123. PMID: 34008218
Inhibitor of:
1200013P24Rik, Arp7, BAZ2B, Bcl-11a, CaBP3, CHRAC15, Cks1, CREB Binding Protein (CBP), EFO1, Elongin C, ELP4, Esa1, ESCO1, FACL5, Fc ε RIγ, GCN5, GHR, Gm608, H2AL1, HAT1, HBO1, HIRA, Histone cluster 1 H1C, Histone cluster 1 H1D, Histone cluster 1 H2AA4, Histone cluster 1 H2BD, Histone cluster 1 H3J, Histone cluster 1 H4I, Histone cluster 2 H2AA1, Histone cluster 2 H2AB, Histone H2B.S, Histone H3.3B, ING5, L3MBTL4, lysine, MOF, MORF, N-myristoyltransferase 2, NAA (N-alpha-acetyltransferase), NAA25, NAT-11, NAT-13, NAT-3, p300, p400, PCAF, PIWIL4, PLAG1, RTF1, SPT3, SRCAP, TADA2L, TAF6L, TMEM103, TMEM108, TRF, TRRAP, Tup1, and YY1.Activator of:
4632411B12Rik, ACTR6, ADA3, ASCL2, Brpf1, BRPF3, caspase-3, CDY, DDX28, EPC1, Eso-1, H1T2, HAT1, Histone cluster 1 H2AH, Histone cluster 1 H2AM, Histone cluster 1 H2BI, Histone cluster 1 H3G, Histone cluster 1 H4, Histone cluster 1 H4H, Histone cluster 2 H2AA3, Histone cluster 2 H2BF, Histone cluster 2 H3C1, Histone cluster 2 H4B, Histone H1, KAT III, MacroH2A1, MEAF6, Med10, Med22, MLL, MORF4L1, MOV10L1, MTGR1, NAT-12, NAT-9, pan-Acetyl, PCAF, QTRTD1, Spt7, Syk, TAF II p28, TBL1Y, TFIID, Tyk 2, UBN-2, ZMYND15, and ZNF766.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Garcinol, 10 mg | sc-200891 | 10 mg | $124.00 | |||
Garcinol, 50 mg | sc-200891A | 50 mg | $502.00 |