Date published: 2025-10-3

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HIP14L Activators

HIP14L, or Huntingtin Interacting Protein 14-Like, is a gene that encodes a protein closely related to HIP14, a member of the palmitoyl transferase family. HIP14L is involved in the process of palmitoylation, a post-translational modification where a palmitic acid is covalently attached to specific cysteine residues in proteins. This modification influences the trafficking, localization, stability, and function of the modified proteins.The HIP14L protein shares structural similarities with HIP14, including DHHC (Asp-His-His-Cys) domain, characteristic of palmitoyl acyltransferases (PATs). This domain is essential for the enzyme's catalytic activity in transferring palmitate to substrate proteins. Palmitoylation by HIP14L is crucial for regulating various cellular processes, including signal transduction, protein sorting, and membrane dynamics.

While HIP14 is known for its interaction with huntingtin, the protein mutated in Huntington's disease, the specific roles and interactions of HIP14L are less well understood. However, given its enzymatic function and similarity to HIP14, HIP14L is likely to interact with a range of substrates, impacting neuronal function and playing a role in neurodegenerative disorders.Studies suggest that dysregulation of palmitoylation enzymes like HIP14L can impact neuronal signaling and health, contributing to the pathogenesis of neurological diseases. Understanding HIP14L's specific functions and substrates could shed light on these processes and offer targets for intervention.

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