HILPDA Activators
Hypoxia Inducible Lipid Droplet Associated (HILPDA) Activators are a class of chemical compounds that have the unique ability to induce the expression and activation of the HILPDA gene. HILPDA, also known as hypoxia-inducible gene 2 (HIG2), is a protein associated with lipid metabolism, and its expression is typically upregulated in response to hypoxia or low oxygen levels. The role of HILPDA in cellular physiology revolves around its involvement in lipid droplet formation and lipid storage within cells. HILPDA activators are essential tools in scientific research for understanding the molecular mechanisms behind lipid metabolism in various cellular contexts, particularly under conditions of reduced oxygen availability.
These activators can belong to different chemical classes, including hypoxia-mimicking agents and compounds that directly modulate the signaling pathways associated with HILPDA regulation. Hypoxia-mimicking agents, such as cobalt chloride (CoCl2), deferoxamine (DFO), and dimethyloxalylglycine (DMOG), can stabilize the Hypoxia-Inducible Factor 1-alpha (HIF-1α) protein, a key regulator of hypoxia responses. When HIF-1α is stabilized, it can translocate to the nucleus and bind to hypoxia-responsive elements in the HILPDA gene promoter, leading to increased HILPDA expression. These agents create a cellular environment similar to hypoxia, triggering HILPDA activation as part of the cellular response to low oxygen conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $255.00 | ||
Deferoxamine is an iron chelator that can induce hypoxia-like conditions by reducing intracellular iron levels. Iron is essential for the activity of prolyl hydroxylases, enzymes that target HIF-1α for degradation. By chelating iron, DFO inhibits these enzymes and leads to HIF-1α stabilization and subsequent HILPDA activation. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
DMOG is a chemical compound that inhibits prolyl hydroxylases in a manner similar to DFO and dipyridyl. By inhibiting prolyl hydroxylases, DMOG can stabilize HIF-1α and promote HILPDA expression. | ||||||
Nickel(II) chloride | 7718-54-9 | sc-236169 sc-236169A | 100 g 500 g | $68.00 $188.00 | ||
Nickel chloride has been shown to stabilize HIF-1α and induce a hypoxia-like response in cells. It can activate HIF-1α target genes, including HILPDA. | ||||||