HFE Inhibitors
HFE inhibitors represent a fascinating class of chemical compounds that primarily target the human hemochromatosis protein, encoded by the HFE gene. These inhibitors play a crucial role in the regulation of iron homeostasis within the body. Iron is an essential element for various physiological processes, including oxygen transport, DNA synthesis, and energy production. However, excessive iron accumulation in the body can lead to severe health issues, such as hemochromatosis, a hereditary disorder characterized by excessive iron absorption. HFE inhibitors are designed to modulate the function of the HFE protein, which is involved in regulating the absorption of dietary iron in the small intestine. By inhibiting this protein, they can potentially help manage iron overload disorders.
The mechanism of action of HFE inhibitors involves interfering with the interaction between the HFE protein and its receptor, transferrin receptor 2 (TfR2). This interaction normally inhibits the production of hepcidin, a hormone that regulates iron absorption and storage in the body. Inhibition of the HFE protein-TfR2 interaction leads to increased hepcidin production, which, in turn, reduces iron absorption from the gut and promotes iron sequestration within cells.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $180.00 | 9 | |
Chelates iron, thereby limiting the availability of iron and reducing oxidative stress, which can indirectly affect HFE protein function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Increases metallothionein that sequesters iron, potentially reducing the interaction of iron with the HFE protein. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Antioxidant properties can reduce oxidative stress, possibly influencing HFE protein function by modulating iron metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Exhibits iron-chelating properties and has been shown to modulate iron homeostasis, affecting the HFE protein indirectly. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Has iron-chelation activity and can alter the expression of genes involved in iron metabolism, potentially impacting HFE function. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $57.00 $72.00 $126.00 | 7 | |
Flavonoid with antioxidant properties that can modulate iron levels and affect HFE protein function indirectly. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Polyphenol with iron-binding capacity, which may influence iron homeostasis and HFE protein's regulatory role. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Flavonoid that can chelate iron, potentially affecting the HFE protein's function in iron metabolism. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $47.00 $69.00 | 1 | |
Has metal-chelating properties that can influence iron metabolism and indirectly affect the function of the HFE protein. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Chelates metals like copper, but also has some affinity for iron, and thus could influence HFE protein function by altering metal availability. | ||||||