HE4 Inhibitors

Regarding the chemical class HE4 Inhibitors, these compounds represent a diverse group that can interact with cellular signaling pathways potentially linked to HE4. Their mechanisms of action include inhibition of Wnt signaling, alteration of protein folding and protein-protein interactions, disruption of cell adhesion and migration processes, and interference with various cancer-related signaling pathways such as MAPK/ERK, PI3K, and mTOR.

These compounds range from naturally occurring polyphenols like EGCG and quercetin to synthetic molecules like IWP-2 and Y-27632. Their action is centered around modulating cellular processes where HE4 is presumed to play a role. By targeting these pathways, these inhibitors aim to indirectly influence the activity of HE4, especially in contexts where it is implicated in abnormal cell behavior.