GTPBP2 Inhibitors
Chemical inhibitors of GTPBP2 play a role in modulating its function by targeting various signaling pathways that indirectly influence its activity in mRNA surveillance. GW5074, a Raf-1 kinase inhibitor, disrupts the MAPK/ERK pathway, which can have downstream effects on the cellular signaling environment of GTPBP2. Similarly, LY294002 and Wortmannin, both inhibitors of PI3K, can alter the PI3K/AKT signaling axis, thereby impacting the processes that GTPBP2 is associated with, such as mRNA decay and quality control. U0126 and PD98059, which selectively inhibit MEK1/2, can impede the phosphorylation and subsequent activation of ERK, a pathway that plays a role in the regulation of mRNA turnover, a process in which GTPBP2 is intimately involved.
Furthermore, SP600125 and SB203580, which are inhibitors of the JNK and p38 MAP kinase pathways respectively, can affect transcriptional regulation and the cellular response to stress, processes that GTPBP2 may be involved in. The inhibition of these kinases can thus influence the functional role of GTPBP2 in the cellular stress response. Rapamycin, an inhibitor of mTOR, can disrupt the signaling pathways that regulate protein synthesis, which is closely tied to the monitoring functions of GTPBP2. The cyclin-dependent kinase inhibitor Roscovitine can lead to changes in the cell cycle, which in turn can have an impact on the cell cycle-dependent aspects of mRNA surveillance by GTPBP2. Lastly, LFM-A13 and PP2, targeting Bruton's tyrosine kinase and Src family kinases respectively, may alter the signaling pathways governing mRNA stability and degradation, and therefore indirectly modulate the activity of GTPBP2 in maintaining mRNA integrity. Each of these inhibitors, by affecting different kinases and signaling pathways, can alter the cellular conditions that are important for the functional performance of GTPBP2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a potent inhibitor of Raf-1 kinase, which interacts with downstream molecules affecting MAPK/ERK pathways. GTPBP2 functions in mRNA monitoring and its activity can be indirectly influenced by changes in cellular signaling cascades. Inhibition of Raf-1 kinase by GW5074 could disrupt signaling pathways that indirectly influence GTPBP2's role in mRNA surveillance. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). PI3K signaling is crucial for many cellular functions and can have downstream effects on mRNA translation and degradation mechanisms. By inhibiting PI3K, LY294002 can indirectly inhibit GTPBP2 by altering signaling pathways that GTPBP2 may rely on for its proper function in mRNA surveillance and turnover. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 selectively inhibits MEK1/2, which are upstream regulators of the ERK pathway. By inhibiting MEK, U0126 can interfere with the phosphorylation and activation of ERK, thereby indirectly inhibiting the GTPBP2 activity by disrupting signaling pathways that may influence GTPBP2’s role in mRNA decay and quality control processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is part of the MAPK signaling pathways. Inhibition of JNK by SP600125 can alter transcriptional regulation and protein synthesis, potentially impacting cellular processes that GTPBP2 is involved in, such as mRNA triage and the resolution of mRNA stress granules, thereby functionally inhibiting GTPBP2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. The p38 MAPK pathway is involved in stress responses, including mRNA decay. By inhibiting p38 MAPK, SB203580 could impede signal transduction processes that may indirectly inhibit GTPBP2's functional role in mRNA turnover, surveillance, and response to cellular stress, which relies on proper signaling through p38 MAPK. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By inhibiting PI3K, it can disrupt downstream signaling pathways that are critical for mRNA metabolism and quality control processes, potentially leading to an indirect functional inhibition of GTPBP2 by altering the signaling environment that GTPBP2 operates within. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key kinase that regulates protein synthesis and cell growth. Since GTPBP2 is associated with the ribosome and involved in mRNA monitoring, inhibiting mTOR with rapamycin can disrupt the signaling pathways that regulate translation, potentially impacting GTPBP2's function in mRNA surveillance indirectly. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which prevents the activation of ERK. By inhibiting this pathway, PD98059 can indirectly inhibit the functional role of GTPBP2 by disrupting cellular signaling mechanisms that influence mRNA turnover and GTPBP2's regulatory actions in mRNA quality control. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a cyclin-dependent kinase (CDK) inhibitor, which can lead to cell cycle arrest. Given that GTPBP2 is involved in mRNA monitoring, the inhibition of CDKs by roscovitine can indirectly inhibit GTPBP2's function by altering cell cycle-dependent mRNA surveillance mechanisms, thereby affecting GTPBP2's role in these processes. | ||||||
LFM-A13 | 62004-35-7 | sc-203623 sc-203623A | 10 mg 50 mg | $119.00 $670.00 | ||
LFM-A13 is a selective inhibitor of Bruton's tyrosine kinase (BTK). While BTK is primarily associated with B cell development, it can also influence signaling pathways that affect mRNA stability and degradation. Inhibiting BTK with LFM-A13 could indirectly inhibit GTPBP2 by altering the cellular signaling context in which GTPBP2 operates its mRNA quality control function. | ||||||