GS2 Activators
GS2 Activators encompass a diverse range of chemical compounds that interact with various cellular signaling pathways and metabolic processes, ultimately influencing lipid metabolism and potentially increasing the functional activity of the GS2 protein. The primary mechanisms through which these activators operate include modulation of cAMP levels, activation of protein kinases such as PKA, and alteration of the lipid environment within cells. Forskolin and Isoproterenol, for example, enhance intracellular cAMP, which in turn activates PKA. PKA is known to phosphorylate a broad spectrum of target proteins, including GS2, which could lead to enhanced activity of GS2.
Compounds like L-Carnitine, Palmitoyl-CoA, and Oleoylethanolamide directly impact the transport, availability, and breakdown of fatty acids, which are critical components of lipid metabolism. By influencing these fundamental aspects, they can indirectly modulate the functional activity of GS2. For instance, L-Carnitine's role in facilitating fatty acid transport into mitochondria for beta-oxidation can modify the cellular fatty acid pool, which may influence the activity of GS2 if it plays a role in lipid metabolism.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels, which can enhance protein kinase A (PKA) activity. PKA phosphorylates lipid-associated proteins, potentially enhancing the lipolytic activity of GS2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, leading to cAMP production and PKA activation. This can enhance lipolysis, possibly increasing the substrate availability for GS2 activity. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic acid binds to the G-protein coupled receptor GPR109A on adipocytes, inhibiting adenylate cyclase activity, thus modulating the lipid signaling environment and potentially influencing the activity of lipid-related proteins like GS2. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine facilitates the transport of fatty acids into mitochondria for beta-oxidation, indirectly affecting the cellular fatty acid pool and potentially enhancing the functional activity of lipid-metabolizing proteins like GS2. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
A cell-permeable cAMP analog that directly activates PKA, enhancing phosphorylation of lipid-associated proteins, which could increase the activity of GS2. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $90.00 $194.00 | 1 | |
Oleoylethanolamide activates PPAR-alpha, a nuclear receptor that regulates lipid metabolism genes, potentially upregulating lipid-metabolizing enzymes and thus indirectly enhancing GS2 activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which can regulate lipid metabolism, possibly enhancing the activity of lipid-associated proteins like GS2. | ||||||
CL 316243 disodium salt | 151126-84-0 | sc-203895 sc-203895A | 10 mg 50 mg | $590.00 $1566.00 | 15 | |
A selective beta-3 adrenergic agonist that induces lipolysis in adipose tissue, potentially increasing the availability of fatty acids and enhancing the activity of lipid-metabolizing proteins like GS2. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist that alters lipid and glucose metabolism, potentially affecting the activity of enzymes involved in these pathways, such as GS2, by altering substrate availability or enzyme regulation. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
A potent and selective PPAR-alpha agonist that could upregulate the expression of genes involved in lipid metabolism, indirectly enhancing the functional activity of lipid-associated proteins like GS2. | ||||||