gremlin-2 Activators
Gremlin-2, a member of the DAN family of BMP (bone morphogenetic protein) antagonists, plays a critical role in various biological processes, including embryonic development, tissue differentiation, and organogenesis. This protein functions by binding to and inhibiting BMPs, thereby regulating the BMP signaling pathway which is essential for the proper development and maintenance of tissue architecture and function. Gremlin-2 is intricately involved in the modulation of cellular processes such as proliferation, differentiation, and apoptosis, acting as a key regulator in the finely tuned balance between developmental and regenerative processes. Its expression and activity are crucial for the development of the cardiovascular system, as well as for the regulation of angiogenesis, the process by which new blood vessels form from pre-existing vessels. This highlights the significance of Gremlin-2 in both physiological and pathological contexts, underpinning its role in maintaining cellular and tissue homeostasis.
The activation of Gremlin-2 involves a complex interplay of molecular signals and regulatory mechanisms that ensure its precise function within the BMP signaling pathway. Gremlin-2 is activated transcriptionally by various signaling pathways, including those mediated by TGF-β (transforming growth factor-beta), which is known to play a pivotal role in cell differentiation and proliferation. Upon activation, Gremlin-2 interacts directly with BMPs, blocking them from binding to their receptors on the cell surface. This inhibition is a crucial regulatory mechanism, as it modulates the downstream signaling cascades initiated by BMPs, leading to the activation or repression of target genes involved in cellular differentiation and development. Additionally, the expression of Gremlin-2 is subject to regulation by epigenetic modifications and by feedback loops within the BMP signaling pathway, ensuring that its activity is finely tuned according to the developmental and physiological needs of the organism. Through these mechanisms, Gremlin-2 serves as a vital modulator of developmental pathways, orchestrating a wide array of cellular fates and functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LDN 193719 | 1062368-49-3 | sc-489383 | 10 mg | $189.00 | ||
LDN 193719 is an inhibitor of BMP receptor kinase ALK2, which could result in feedback activation of BMP signaling. This potential increase in signaling may enhance the context in which gremlin-2 can interact with BMP ligands, thus amplifying its biological activity. | ||||||
K02288 | 1431985-92-0 | sc-488981 | 5 mg | $330.00 | ||
K02288 is a potent and selective inhibitor of ALK2 and ALK3 receptors. By modulating these receptors, it can indirectly lead to increased BMP signaling in certain contexts, which in turn could elevate gremlin-2 activity. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Although primarily an Aurora B kinase inhibitor, hesperadin can affect multiple signaling pathways. If BMP signaling is indirectly upregulated as a compensatory response to its inhibition of other pathways, it could inadvertently increase the activity of gremlin-2. | ||||||
LDN-214117 | 1627503-67-6 | sc-507451 | 5 mg | $165.00 | ||
LDN-214117 selectively inhibits BMP receptor kinase ALK2. Though an inhibitor, its action can lead to a feedback increase in BMP signaling, indirectly heightening the activity of gremlin-2. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate, a PPARα agonist, is traditionally used for lipid metabolism regulation. However, PPARα activation can also modulate various growth factors and cytokines, potentially leading to a complex regulatory effect on BMP signaling and consequently an indirect activation on gremlin-2 activity. | ||||||