granzyme D Activators
Cells possess coordinated intracellular networks that tightly control granzyme D performance of its specialized apoptosis functions. Second messengers relay signals modulating granzyme D activity under stressful conditions. DNA damaging agents generate a wave of signaling cascades culminating in kinase activation and transcriptional upregulation of granzyme D. Compounds like idarubicin, doxorubicin and etoposide precisely manipulate these intracellular rheostats to maximally enhance granzyme D expression and proteolytic function. Cytokines provide another control interface potentiating granzyme D output at multiple levels. Agents stimulating cytokine production like metoclopramide optimize conditions conducive to triggering apoptosis. Collectively, these compounds exert potent effects optimizing intracellular signaling dynamics and transcriptional control governing granzyme D execution of its apoptotic duties through diverse modes of action.
Additionally, mitochondrial poisons valinomycin and amphotericin B enlist granzyme D clearance of compromised organelles. Histone inhibitors apicidin and genotoxins azidothymidine and streptozotocin activate granzyme D-dependent protective programs. Cytokine stimulators like metoclopramide upregulate granzyme D expression levels to enhance apoptosis signaling capacity. Collectively, these agents utilize granzyme D as an adaptive stress response effector through well-integrated signaling coordination.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Idarubicin | 58957-92-9 | sc-507346 | 10 mg | $180.00 | ||
Idarubicin generates DNA adducts and reactive oxygen species. Granzyme D induces apoptosis through selective proteolysis of inhibitor of caspase-activated DNase. Idarubicin treatment stimulates the apoptotic functions of granzyme D to clear damaged cells. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Similar to idarubicin, doxorubicin triggers DNA damage and oxidative stress to activate granzyme D-mediated apoptosis for genomic maintenance. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin cross-links DNA to induce lethal DNA damage. Granzyme D eliminate cisplatin-compromised cells through targeted proteolysis in apoptotic pathways. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, triggering DNA strand breaks. Granzyme D plays a complementary role in eliminating etoposide-injured cells. | ||||||
Sulfathiazole | 72-14-0 | sc-215927 sc-215927A | 100 mg 1 g | $102.00 $82.00 | ||
Mitoxantrone intercalates DNA and generates cytotoxic radical species. Granzyme D coordinates apoptosis signaling to remove mitoxantrone-exposed cells and maintain genomic integrity. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin dissipates mitochondrial membrane potential. Granzyme D-deficient cells demonstrate impaired mitochondrial clearance. Valinomycin induces an adaptive response in granzyme D performance of this function. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $110.00 $343.00 | 9 | |
Apicidin inhibits histone deacetylases and causes DNA damage. Granzyme D resolves DNA lesions induced by apicidin exposure through selective proteolysis. | ||||||
Amphotericin B | 1397-89-3 | sc-202462 sc-202462A sc-202462B | 100 mg 500 mg 1 g | $70.00 $142.00 $223.00 | 10 | |
Amphotericin B generates oxidative radicals and lipid peroxides. Granzyme D activates protective mitochondrial elimination programs against this membrane injury. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
Azidothymidine triggers DNA strand scission. Granzyme D acts coordinately to remove azidothymidine-compromised cells from affected tissues. | ||||||
Streptozotocin (U-9889) | 18883-66-4 | sc-200719 sc-200719A | 1 g 5 g | $116.00 $530.00 | 152 | |
Streptozotocin alkylates DNA to induce lesions. Granzyme D resolves such genotoxic insults through selective elimination of affected host cells. | ||||||