GPx-3 Inhibitors
The chemical class of GPx-3 Inhibitors includes a variety of compounds known to influence the function and availability of GPx-3. Heavy metals and their compounds, such as Mercury, Cadmium, Arsenic, and Lead, are known to interact with and potentially inhibit selenoproteins like GPx-3. Methylmercury and Auranofin are examples of compounds that can bind to and inhibit the function of selenoproteins.
N-Ethylmaleimide and Buthionine Sulfoximine specifically target glutathione, a substrate necessary for GPx-3 activity, either by reacting with sulfhydryl groups or inhibiting its synthesis. Chelating agents like Deferoxamine and 2,3-Dimercapto-1-propanol might interfere with the metal-dependent activity of GPx-3. Propylthiouracil and Diethyl Maleate can influence selenium metabolism and glutathione levels, respectively, potentially leading to reduced GPx-3 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
A compound that reacts with sulfhydryl groups, potentially inhibiting enzymes like GPx-3 that require glutathione as a substrate. | ||||||
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $286.00 $442.00 $1532.00 $2975.00 | 26 | |
An inhibitor of glutathione synthesis, reducing the availability of glutathione, which is necessary for GPx-3 activity. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
A gold-containing compound that can inhibit selenoenzymes like GPx-3. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1060.00 $2923.00 $4392.00 $8333.00 | 19 | |
A chelating agent that might interfere with metal-dependent enzymes, potentially affecting GPx-3 activity. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
Used for hyperthyroidism, this compound can influence selenium metabolism and potentially inhibit GPx-3. | ||||||
Diethylmaleate | 141-05-9 | sc-202577 | 5 g | $27.00 | 4 | |
A compound that can deplete glutathione levels, potentially inhibiting GPx-3 activity due to reduced substrate availability. | ||||||