Gm75 Inhibitors
Chemical inhibitors of Gm75 function by impeding the activity of cyclin-dependent kinases (CDKs), which are integral to the regulation of the cell cycle. Alsterpaullone, Roscovitine, and Olomoucine exhibit this inhibitory action by targeting various CDKs essential for the progression of cells through the cell cycle phases. For instance, Olomoucine exhibits a selective inhibition of CDKs, particularly CDK1, CDK2, and CDK5, enzymes that have a pivotal role in cell cycle regulation. Purvalanol A extends this inhibition to CDK4 and CDK6, which are also involved in cell cycle control. These inhibitors can halt the cell cycle at specific checkpoints, thereby functionally inhibiting Gm75 by preventing the sequence of events necessary for cell cycle progression.
Continuing this theme of cell cycle disruption, several other inhibitors act to impede CDKs that Gm75 relies upon for its activity. PD0332991, also known as Palbociclib, and Ribociclib, specifically target CDK4/6, arresting the cell cycle in the G1 phase. Similarly, AZD5438 and Dinaciclib target a broader range of CDKs, including CDK1, CDK2, and CDK9, which play critical roles in both cell cycle progression and transcription regulation. Flavopiridol primarily inhibits CDK9, which is crucial for transcription elongation, thereby disrupting processes vital for Gm75 activity. Milciclib, on the other hand, targets multiple CDKs and affects cyclin D1 expression, leading to cell cycle arrest. Lastly, SNS-032 selectively inhibits CDK2, CDK7, and CDK9, which are key players in both cell cycle progression and transcription regulation. The inhibition of these kinases by SNS-032 can suppress critical pathways required for Gm75 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that can inhibit CDKs which are critical for the cell cycle. Gm75 activity is related to cell cycle regulation, and inhibition of CDKs can lead to the functional inhibition of Gm75. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is another CDK inhibitor, which, similar to Alsterpaullone, can suppress the activity of CDKs involved in cell cycle control, thereby functionally inhibiting Gm75 by preventing progression through the cell cycle. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is a selective inhibitor of CDKs, especially CDK1, CDK2, and CDK5, which are involved in cell cycle regulation. By inhibiting these kinases, Olomoucine can lead to the functional inhibition of Gm75. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a potent inhibitor of CDKs, including CDK1, CDK2, CDK4, and CDK6. As these kinases play a role in cell cycle regulation, their inhibition can result in the functional inhibition of Gm75. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
PD0332991, also known as Palbociclib, selectively inhibits CDK4/6, which are involved in the transition from G1 to S phase of the cell cycle. Inhibition of these kinases can lead to functional inhibition of Gm75. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD5438 inhibits CDK1, CDK2, and CDK9, which are important for both cell cycle progression and transcription regulation. Through inhibiting these kinases, AZD5438 can functionally inhibit Gm75. | ||||||
Ribociclib | 1211441-98-3 | sc-507367 | 10 mg | $450.00 | ||
Ribociclib is a CDK4/6 inhibitor, similar to PD0332991, which can arrest the cell cycle in the G1 phase, thereby functionally inhibiting Gm75 by halting cell cycle-dependent processes that Gm75 is involved in. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib strongly inhibits CDK1, CDK2, CDK5, and CDK9. This broad inhibition of CDKs can interfere with the cell cycle and transcription regulation, leading to functional inhibition of Gm75. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits CDKs, particularly CDK9 which is involved in transcription elongation. Through CDK9 inhibition, Flavopiridol can disrupt processes that are essential for Gm75 activity, thus functionally inhibiting it. | ||||||
PHA-848125 | 802539-81-7 | sc-364581 sc-364581A | 5 mg 10 mg | $304.00 $555.00 | ||
Milciclib targets multiple CDKs and can inhibit cyclin D1 expression, leading to cell cycle arrest. By targeting these kinases and cyclin expression, Milciclib can functionally inhibit Gm75. | ||||||