Gm606 Inhibitors

The chemical class of Gmnc Inhibitors comprises compounds that indirectly affect the function of geminin coiled-coil domain containing (Gmnc) through the modulation of cell cycle-related pathways and processes. These compounds can alter the cellular environment and regulatory networks in which Gmnc operates, rather than binding to or directly inhibiting the protein.

Compounds such as Roscovitine, Olomoucine, Purvalanol A, Flavopiridol, Palbociclib, Ribociclib, PD0332991, Abemaciclib, and Dinaciclib are inhibitors of cyclin-dependent kinases (CDKs), which are critical for the progression of the cell cycle. By inhibiting CDKs, these compounds can disrupt the tightly regulated process of cell cycle progression, potentially affecting the activity or stability of Gmnc. Since Gmnc is involved in cell cycle regulation, alterations in CDK activity can indirectly influence Gmnc's role. Other compounds like Aphidicolin, Hydroxyurea, and Nocodazole act through different mechanisms but similarly result in cell cycle arrest. Aphidicolin inhibits DNA polymerase, Hydroxyurea targets ribonucleotide reductase, and Nocodazole disrupts microtubule polymerization, all of which lead to halting the cell cycle. Cell cycle arrest can affect the cellular context and the regulatory mechanisms controlling Gmnc, hence modulating its function.