Get4 Activators
Get4, also known as Golgi to ER Traffic Protein 4, is a protein involved in the process of protein targeting to the endoplasmic reticulum (ER). It's a component of the GET (Golgi-to-ER trafficking) complex, which is responsible for the delivery of tail-anchored (TA) proteins to the ER in both yeast and mammalian cells.TA proteins have a single transmembrane domain near their C-terminus and play crucial roles in various cellular processes, including vesicular trafficking, cell signaling, and protein translocation. However, the hydrophobicity of the transmembrane domain makes the delivery and insertion of TA proteins into the ER membrane a challenging process, which is where the GET complex comes in.
Get4 plays a central role within this complex. It forms a subcomplex with Get5 (also known as Ubl4A in mammals) and binds to Sgt2 (small glutamine-rich tetratricopeptide repeat-containing protein), which initially recognizes and binds the TA proteins. Get4 is essential for the handover of TA substrates from Sgt2 to the main GET complex for their subsequent insertion into the ER.In summary, Get4 is a crucial component of the GET complex, playing a key role in the delivery of tail-anchored proteins to the endoplasmic reticulum. Its function is critical for maintaining cellular homeostasis and proper functioning, given the wide range of cellular processes that TA proteins are involved in.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts ER calcium storage, inducing ER stress and potentially upregulating factors involved in protein homeostasis. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can regulate genes involved in stress responses, possibly including those coding for ER-associated proteins. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which may alter cellular processes and the expression of proteins involved in membrane trafficking. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, sodium butyrate can increase the expression of various genes by altering chromatin structure, potentially affecting Get4. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts ER to Golgi trafficking, which could lead to a compensatory upregulation of proteins in the trafficking pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that could lead to accumulation of misfolded proteins, triggering an unfolded protein response and possibly enhancing Get4 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been found to affect a variety of signaling pathways and may influence the expression of proteins involved in the ER stress response. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride affects GSK-3β signaling and might indirectly influence the expression of proteins involved in protein trafficking. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine affects lysosomal function and autophagy, which can lead to cellular stress responses and potentially influence the expression of trafficking proteins. | ||||||