Date published: 2026-5-5

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General Crosslinkers

Santa Cruz Biotechnology now offers a broad range of crosslinkers for use in various applications. Crosslinkers are versatile chemical agents that can form covalent bonds between different molecules, thus linking them together. These compounds are crucial in scientific research for stabilizing the structure of proteins, nucleic acids, and other biomolecules, allowing for more accurate studies of their functions and interactions. By creating crosslinked networks, researchers can investigate the three-dimensional structure of macromolecules, study the dynamics of complex biological systems, and enhance the durability and functionality of biomaterials. In material science, crosslinkers are used to develop polymers with improved mechanical properties, such as increased strength and resistance to solvents and heat. Additionally, they play a vital role in developing and optimizing new materials, adhesives, coatings, and composites. The ability of crosslinkers to create strong, stable bonds has also been utilized in various biochemical techniques, such as immunoprecipitation, chromatography, and mass spectrometry, where they help in isolating and identifying specific molecules from complex mixtures. Santa Cruz Biotechnology provides a wide selection of crosslinkers, each with unique properties tailored for specific research needs, ensuring researchers have the tools necessary for their studies. View detailed information on our available crosslinkers by clicking on the product name.

Items 81 to 90 of 343 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

11-Maleimidoundecanoic Acid

57079-01-3sc-357488
sc-357488A
sc-357488B
sc-357488C
100 mg
250 mg
500 mg
1 g
$199.00
$352.00
$571.00
$765.00
(0)

11-Maleimidoundecanoic Acid serves as an effective crosslinker, notable for its maleimide functionality that selectively reacts with thiol groups, enabling the formation of stable covalent bonds. This specificity enhances the structural integrity of polymer matrices. The compound exhibits favorable reaction kinetics, allowing for efficient crosslinking under mild conditions. Its hydrophobic tail contributes to improved solubility and compatibility in diverse environments, promoting versatile applications in material science.

N-Succinimidyl-p-Formylbenzoate

60444-78-2sc-212281
sc-212281A
sc-212281B
100 mg
250 mg
1 g
$141.00
$228.00
$583.00
(1)

N-Succinimidyl-p-Formylbenzoate serves as an effective crosslinker, distinguished by its formyl group that enhances reactivity towards amines, facilitating the formation of stable imine bonds. This compound exhibits a high degree of specificity in targeting functional groups, allowing for precise control over crosslinking density. Its unique structure promotes efficient reaction kinetics, enabling rapid formation of covalent linkages, which is crucial for studying complex molecular assemblies and interactions.

Disuccinimidyl L-Tartrate

62069-75-4sc-211361
250 mg
$218.00
(0)

Disuccinimidyl L-Tartrate is a versatile crosslinker known for its ability to form stable amide bonds through its reactive succinimidyl groups. This compound exhibits a unique capacity for facilitating the formation of complex networks in biomolecular assemblies, enhancing structural integrity. Its bifunctional nature allows for selective targeting of multiple sites, promoting efficient crosslinking. The compound's hydrophilicity aids in solubility, ensuring uniform distribution in aqueous environments, which is crucial for consistent reaction kinetics.

N-[4-(-Carboxycyclohexylmethyl)]maleimide

64987-82-2sc-212048
20 mg
$150.00
(0)

N-[4-(-Carboxycyclohexylmethyl)]maleimide acts as a versatile crosslinker, characterized by its maleimide moiety that readily engages in thiol-ene click reactions, promoting robust covalent bonding. The carboxycyclohexyl group enhances steric hindrance, leading to increased network stability and mechanical strength. Its unique structure allows for tailored reactivity and compatibility with various substrates, facilitating the formation of intricate polymer architectures with desirable physical properties.

2-(Boc-amino)ethanethiol

67385-09-5sc-237864
5 g
$62.00
(0)

2-(Boc-amino)ethanethiol serves as a versatile crosslinker, characterized by its thiol functional group that facilitates thiol-ene and thiol-disulfide exchange reactions. This compound exhibits a high degree of reactivity, allowing for rapid crosslinking under mild conditions. Its Boc (tert-butyloxycarbonyl) protecting group enhances stability during storage and handling, while also enabling selective deprotection for targeted functionalization. The resulting networks exhibit improved elasticity and resilience, making them suitable for diverse applications.

3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl Bis-bromide

67705-77-5sc-209730
100 mg
$360.00
(0)

3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl Bis-bromide functions as a versatile crosslinker, characterized by its unique bromide functionalities that enable rapid halogenation reactions. The extended pentaoxaheptadecane chain enhances solubility and facilitates effective molecular interactions, leading to a dynamic crosslinking process. This compound's ability to form stable covalent bonds contributes to the creation of highly durable networks, optimizing material performance under various conditions.

3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester

68181-17-9sc-209453
100 mg
$398.00
1
(0)

3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester serves as an effective crosslinker, characterized by its ability to form stable thioether bonds through nucleophilic attack. The pyridyl moiety enhances reactivity, promoting selective conjugation with thiol-containing biomolecules. Its unique reaction kinetics allow for rapid crosslinking under mild conditions, facilitating the formation of complex networks. This compound's distinct molecular interactions enable precise control over spatial arrangement in bioconjugation applications.

3-(2-Pyridyldithio)propanoic Acid

68617-64-1sc-359036
250 mg
$430.00
(0)

3-(2-Pyridyldithio)propanoic Acid serves as an effective crosslinker, characterized by its ability to form disulfide bonds through thiol exchange reactions. This compound facilitates the creation of robust networks by promoting unique molecular interactions between thiol groups, enhancing structural integrity. Its reactivity is influenced by the pyridine moiety, which can engage in coordination with metal ions, potentially altering reaction pathways and kinetics. This versatility allows for the design of complex materials with tailored properties.

Dibromobimane

68654-25-1sc-211300
25 mg
$180.00
2
(0)

Dibromobimane is a versatile crosslinker known for its ability to form stable covalent bonds with thiol groups in proteins, leading to the creation of robust polymer networks. Its unique dibromobimane structure promotes rapid reaction kinetics, enabling efficient crosslinking under mild conditions. The compound exhibits strong fluorescence properties, allowing for easy tracking of crosslinked structures. Additionally, its hydrophobic nature enhances compatibility with various organic matrices, facilitating diverse applications in material science.

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)

70539-42-3sc-252807
sc-252807A
250 mg
1 g
$129.00
$406.00
2
(0)

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) serves as an effective crosslinker, facilitating the formation of robust polymer networks through its reactive ester groups. These groups engage in dynamic covalent bonding, enhancing mechanical strength and thermal stability in materials. The compound's unique ability to create multi-functional linkages allows for tailored properties in various formulations, while its controlled reaction kinetics enable precise manipulation of crosslink density, optimizing performance in diverse applications.