Date published: 2026-5-6

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General Crosslinkers

Santa Cruz Biotechnology now offers a broad range of crosslinkers for use in various applications. Crosslinkers are versatile chemical agents that can form covalent bonds between different molecules, thus linking them together. These compounds are crucial in scientific research for stabilizing the structure of proteins, nucleic acids, and other biomolecules, allowing for more accurate studies of their functions and interactions. By creating crosslinked networks, researchers can investigate the three-dimensional structure of macromolecules, study the dynamics of complex biological systems, and enhance the durability and functionality of biomaterials. In material science, crosslinkers are used to develop polymers with improved mechanical properties, such as increased strength and resistance to solvents and heat. Additionally, they play a vital role in developing and optimizing new materials, adhesives, coatings, and composites. The ability of crosslinkers to create strong, stable bonds has also been utilized in various biochemical techniques, such as immunoprecipitation, chromatography, and mass spectrometry, where they help in isolating and identifying specific molecules from complex mixtures. Santa Cruz Biotechnology provides a wide selection of crosslinkers, each with unique properties tailored for specific research needs, ensuring researchers have the tools necessary for their studies. View detailed information on our available crosslinkers by clicking on the product name.

Items 131 to 140 of 343 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Thiocholesterol

1249-81-6sc-213033
1 g
$594.00
(0)

Thiocholesterol acts as an effective crosslinker, distinguished by its thiol groups that enable strong covalent bonding through disulfide linkages. This compound exhibits unique reactivity with electrophiles, facilitating selective crosslinking in diverse environments. Its hydrophobic nature enhances compatibility with lipid-based systems, promoting stable network formation. The presence of sulfur atoms contributes to distinct electronic properties, influencing reaction kinetics and enhancing material resilience.

mono-Methyl 5-nitroisophthalate

1955-46-0sc-228612
100 g
$85.00
(0)

Mono-Methyl 5-nitroisophthalate acts as a distinctive crosslinker, characterized by its nitro and ester groups that promote strong intermolecular interactions. The nitro group enhances electron-withdrawing properties, facilitating nucleophilic attack during crosslinking reactions. Its rigid aromatic structure contributes to thermal stability and influences the morphology of polymer networks. Additionally, the compound's ability to engage in hydrogen bonding can significantly affect the mechanical properties of the resulting materials.

Phthalimidoacetaldehyde

2913-97-5sc-219615
1 g
$320.00
(0)

Phthalimidoacetaldehyde serves as an effective crosslinker due to its ability to form stable covalent bonds through nucleophilic attack on electrophilic sites. Its unique structure allows for selective interactions with amines and thiols, promoting the formation of robust networks in polymer matrices. The compound's reactivity is influenced by its electron-withdrawing groups, which enhance its electrophilicity, leading to rapid reaction kinetics. This facilitates the development of tailored materials with enhanced mechanical properties.

Ethylene-bis-maleimide

5132-30-9sc-358228
100 mg
$228.00
(0)

Ethylene-bis-maleimide serves as a versatile crosslinker, characterized by its ability to form robust covalent bonds through Diels-Alder reactions. Its unique structure allows for selective reactivity with nucleophiles, facilitating the creation of thermoset polymers with enhanced thermal stability and mechanical strength. The compound's reactivity is influenced by its electron-deficient double bonds, promoting rapid crosslinking kinetics and enabling tailored material properties for diverse applications.

4-Aminobutyraldehyde diethyl acetal

6346-09-4sc-256675
sc-256675A
5 g
25 g
$57.00
$187.00
(0)

4-Aminobutyraldehyde diethyl acetal serves as a versatile crosslinker, characterized by its ability to form stable covalent bonds through its aldehyde functionality. This compound exhibits unique reactivity with amines and alcohols, enabling the creation of intricate polymer networks. Its low viscosity enhances processing ease, while its selective reactivity allows for controlled crosslinking, leading to improved mechanical properties and thermal stability in composite materials.

6-(Z-Amino)-1-hexanol

17996-12-2sc-254867
1 g
$107.00
(0)

6-(Z-Amino)-1-hexanol serves as a versatile crosslinker, characterized by its long carbon chain that enhances flexibility and mobility within polymer matrices. The primary amine group facilitates robust nucleophilic interactions, promoting effective crosslinking through diverse reaction mechanisms. Its unique molecular architecture allows for enhanced compatibility with various substrates, leading to improved mechanical properties and thermal stability in the resulting networks.

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

55750-63-5sc-239101
1 g
$90.00
(0)

6-Maleimidohexanoic acid N-hydroxysuccinimide ester acts as a versatile crosslinker, characterized by its ability to engage in selective Michael addition reactions with thiol groups. This compound exhibits a unique balance of hydrophobic and hydrophilic characteristics, promoting effective integration into diverse polymer matrices. Its rapid reaction kinetics enable efficient crosslinking, resulting in robust networks with enhanced stability and tailored functional properties.

1,8-Diazido-3,6-dioxaoctane

59559-06-7sc-208814
1 g
$576.00
(0)

1,8-Diazido-3,6-dioxaoctane is a versatile crosslinker characterized by its unique dioxaoctane structure, which enhances its solubility in various solvents. The presence of azide groups allows for efficient click chemistry, promoting rapid and selective reactions with terminal alkynes. This compound's distinct molecular architecture facilitates the formation of robust three-dimensional networks, improving the thermal and mechanical stability of polymer systems while enabling tailored material properties through controlled crosslinking density.

4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid

85559-46-2sc-209896
5 mg
$360.00
(0)

4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid serves as a potent crosslinker, characterized by its diazirine moiety, which facilitates photochemical reactions upon UV exposure. This compound exhibits unique reactivity due to the trifluoromethyl group, enhancing its stability and interaction with various substrates. Its ability to form covalent bonds through radical mechanisms allows for precise control over polymer networks, enabling the design of materials with tailored properties and functionalities.

1,11-Bismaleimidotetraethyleneglycol

86099-06-1sc-208715
25 mg
$330.00
(0)

1,11-Bismaleimidotetraethyleneglycol is a versatile crosslinker characterized by its unique structure featuring multiple maleimide functionalities. This compound facilitates the formation of robust covalent bonds through thiol-maleimide click chemistry, ensuring high specificity and efficiency in crosslinking reactions. Its tetraethylene glycol backbone imparts enhanced solubility and flexibility, allowing for tailored network formation. The compound's reactivity is finely tuned, enabling precise control over crosslink density and network properties, making it ideal for a variety of applications.