GCAP3 Activators
GCAP3 Activators encompass a range of chemical compounds that operate through distinct mechanisms to enhance the activity of GCAP3, a protein implicated in the regulation of guanylate cyclase activity in response to calcium levels. Phospholipids like phosphatidylserine and sterols such as cholesterol are essential for modulating the lipid bilayer where GCAP3 operates, thus optimizing the protein's spatial orientation and interaction with target enzymes. Intracellular messengers and ions, such as calcium and magnesium, are modulated by agents like Calcium ionophore A23187 and magnesium chloride, directly affecting GCAP3's conformation and its capacity to activate guanylate cyclase.
Additionally, nucleotides and their analogs, including GTP and 8-Bromo-cGMP, are tuned by these activators to supply the substrate for and simulate the product of the guanylate cyclase reaction, respectively, each fostering the enhancement of GCAP3. The regulation of secondary messenger systems is a key aspect of GCAP3 activation. Forskolin raises cAMP levels, facilitating protein kinase A (PKA) mediated phosphorylations that can affect GCAP3's activity. Similarly, nitric oxide donors and L-Arginine induce the synthesis of nitric oxide, a potent stimulator of guanylate cyclase, thereby heightening the cGMP production which GCAP3 is known to influence. Thapsigargin and zinc acetate act by manipulating intracellular calcium and zinc concentrations, respectively, each contributing to an environment that promotes GCAP3's activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Phosphatidylserine is a phospholipid component typically found on the inner leaflet of the plasma membrane. It can enhance the activity of GCAP3 by altering the membrane environment, thereby facilitating the association of GCAP3 with its target membrane proteins or receptors. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium levels, which can enhance GCAP3 function by promoting its calcium-binding activity, essential for its role in calcium-mediated signaling pathways. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium chloride can enhance the activity of GCAP3 by stabilizing the protein structure or by facilitating its interaction with target enzymes like guanylate cyclase, which requires magnesium as a cofactor. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium fluoride acts as a phosphatase inhibitor, potentially increasing the phosphorylation status of proteins within GCAP3's signaling pathways, thereby enhancing GCAP3's interaction with phosphorylated target proteins. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can indirectly enhance GCAP3 activity by cAMP-dependent protein kinase (PKA) phosphorylations within GCAP3's signaling network. | ||||||
8-Bromoguanosine 3′, 5′ -cyclic monophosphoric acid | 31356-94-2 | sc-291685 sc-291685A | 5 mg 10 mg | $116.00 $206.00 | ||
8-Bromo-cGMP serves as a cell-permeable analog of cyclic guanosine monophosphate (cGMP), which can enhance GCAP3 by mimicking the action of cGMP and potentially facilitating GCAP3-mediated cGMP production. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is a major component of cellular membranes, and its presence can modulate the lipid microenvironment, potentially enhancing the functional activity of GCAP3 by optimizing its membrane interactions. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acetate can provide zinc ions, which may serve as allosteric modulators of GCAP3 or its target proteins, thus indirectly enhancing the functional activity of GCAP3 in zinc-dependent signaling pathways. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a precursor to nitric oxide synthesis. Elevated nitric oxide levels can enhance GCAP3 activity by stimulating guanylate cyclase and increasing cGMP production. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. Elevated calcium can enhance GCAP3 by promoting its activation state in calcium-dependent signaling events. | ||||||