GBP4 Activators
GBP4 activators constitute a chemical class that indirectly influences the activity or expression of Guanylate Binding Protein 4, primarily through modulation of immune response pathways. These activators include a variety of compounds that stimulate the immune system, leading to the upregulation of GBP4, which is integral to the body's defense mechanisms against infections. Interferon-gamma (IFN-γ), a key cytokine in the immune system, stands out as it can directly induce the expression of GBP4. Similarly, Lipopolysaccharides (LPS), components of bacterial cell walls, and synthetic immune stimulants like Imiquimod and Gardiquimod, activate immune responses that can lead to the upregulation of GBP4. These compounds do not interact directly with GBP4 but exert their influence by activating the pathways that lead to its increased expression or activity.
Additionally, compounds like Poly(I:C), a synthetic analog of double-stranded RNA, and 5'-Triphosphate RNA, known for their role in antiviral defense, can activate pathways leading to GBP4 upregulation. Thiazoloquinolone enhances interferon signaling, which is closely related to GBP4 expression. R848 (Resiquimod) and 2',3'-cGAMP, by acting as immune response modifiers, also play a role in modulating GBP4 activity. Lastly, Pam3CSK4, a synthetic lipopeptide, by mimicking bacterial components, can activate immune responses, indirectly influencing GBP4.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS, components of the outer membrane of Gram-negative bacteria, can stimulate immune responses, potentially enhancing GBP4 expression. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
As an immune response modifier, Imiquimod can induce the production of various cytokines, possibly influencing GBP4 expression. | ||||||
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $198.00 | ||
This synthetic analog of double-stranded RNA can activate immune responses, potentially upregulating GBP4 in the context of antiviral defense. | ||||||
CGS 21680 Hydrochloride | 124431-80-7 | sc-211062 sc-211062A | 10 mg 50 mg | $292.00 $1044.00 | 7 | |
An analog of Imiquimod, Gardiquimod can trigger immune responses that might influence GBP4 activity. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
An immune response modifier that can enhance cytokine production, potentially impacting GBP4 expression. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
A synthetic lipopeptide that mimics bacterial lipoproteins, Pam3CSK4 can activate immune responses, which might influence GBP4 activity. | ||||||