Date published: 2025-9-17

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γ-casein Inhibitors

Casein alpha s2-like A is a protein that is homologous to the alpha-s2 casein proteins found in mammalian milk. Alpha-s2 caseins are one of the several casein proteins, which include alpha-s1, beta, and kappa caseins, and are the main proteins found in milk. They play a critical role in the nutrition and development of neonates, providing essential amino acids, calcium, and phosphate.The alpha-s2 casein proteins are characterized by their ability to stabilize calcium phosphate in the formation of micelles, which are colloidal particles in milk. These micelles are important for the transport of calcium, phosphate, and casein molecules during digestion. They also facilitate the slow digestion of milk, providing a sustained release of amino acids, which is essential for the growth and development of neonates.

As a member of the casein family, casein alpha s2-like A would likely share these properties. It may be involved in the formation of micelles and play a role in the transport and bioavailability of calcium and phosphate. This protein could be expressed in the mammary gland and secreted into milk, where it would contribute to the milk's nutritional profile.Given its structural and functional similarity to other casein proteins, casein alpha s2-like A would be expected to undergo specific post-translational modifications, such as phosphorylation. These modifications can influence the protein's ability to bind calcium and interact with other casein molecules, which is crucial for micelle stability and function.In summary, casein alpha s2-like A, as a homolog of alpha-s2 caseins, would be anticipated to play a role in milk's nutritional properties, particularly in stabilizing calcium phosphate and forming micelles, which are essential for the efficient delivery of nutrients to mammalian offspring. Its presence and function in milk underline its importance in mammalian biology, particularly in early development.

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