galectin-12 Activators
Galectin-12 activators belong to a distinctive chemical class that plays a pivotal role in modulating cellular processes and signaling pathways. Galectins are a family of evolutionarily conserved proteins known for their ability to bind β-galactosides, thereby participating in various physiological and pathological functions. Galectin-12, in particular, is a member of this family that exhibits unique properties. The activators of galectin-12, which induce or enhance its biological activity, are of interest due to their potential to influence cellular responses in a targeted manner.
The structural and functional characteristics of galectin-12 activators contribute to their biological significance. Galectin-12 itself is typically involved in regulating inflammatory responses and immune cell functions, making its activators key modulators in these pathways. The binding of galectin-12 activators to the protein can lead to conformational changes, influencing its interactions with other cellular components. Consequently, these activators have the capacity to fine-tune cellular processes by affecting the functions of galectin-12 in a context-dependent manner. The exploration of galectin-12 activators provides valuable insights into the intricate network of molecular events governing cellular behavior, offering a potential avenue for targeted manipulation of cellular functions in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Galactose | 59-23-4 | sc-202564 | 100 g | $288.00 | 4 | |
Galactose, a monosaccharide sugar, can bind to galectins and potentially alter their conformation and activity. Galectin-12 has carbohydrate recognition domains that can bind galactose, potentially enhancing its carbohydrate-binding ability and influencing its role in lipid metabolism and adipocyte function. | ||||||
Fucoidan | 9072-19-9 | sc-255187 sc-255187A | 5 g 10 g | $190.00 $318.00 | 7 | |
Fucoidan, a sulfated polysaccharide, can bind to galectins, altering their activity. For galectin-12, fucoidan binding can enhance its role in immune cell regulation and inflammatory response, as galectin-12 is involved in modulating leukocyte function and migration. | ||||||
Pectin from citrus peel | 9000-69-5 | sc-255409 sc-255409A | 100 g 500 g | $65.00 $194.00 | 1 | |
Pectin, a complex polysaccharide found in plant cell walls, can interact with galectin-12. This interaction can enhance galectin-12 mediated cellular processes such as cell adhesion and migration, which are crucial in tissue repair and fibrosis. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine, an indolizidine alkaloid, can inhibit glycosidases and thus modulate glycosylation patterns. This modulation can enhance galectin-12's binding to improperly glycosylated proteins, thereby influencing its role in protein quality control within the endoplasmic reticulum and the unfolded protein response pathway. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine is an alkaloid that inhibits mannosidase, altering glycosylation patterns. This alteration can increase the binding of galectin-12 to misfolded glycoproteins, enhancing its role in regulating the unfolded protein response and potentially affecting cellular stress mechanisms. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin is an iminosugar that inhibits alpha-glucosidase, impacting glycoprotein processing. This influence can potentiate galectin-12's interaction with aberrantly glycosylated proteins, thereby enhancing its involvement in pathways like the regulation of the unfolded protein response and adipocyte function. | ||||||