Galactose Mutarotase Inhibitors
Chemical inhibitors of Galactose Mutarotase can act through various mechanisms to impede its function in the metabolism of galactose. Phloretin, a dihydrochalcone phenol, disrupts glucose transporters and indirectly limits the substrate availability for Galactose Mutarotase, consequently reducing its catalytic action on galactose. Quercetin and Fisetin, both flavonoids, exhibit enzyme inhibition by binding to the active or allosteric sites of Galactose Mutarotase, thereby preventing the enzyme from interacting with its substrate, galactose. Epigallocatechin gallate (EGCG), another potent catechin, also targets the active sites of enzymes, which would include those of Galactose Mutarotase, hindering its ability to catalyze the conversion of galactose. Additionally, Kaempferol can compete with galactose for binding to Galactose Mutarotase, effectively inhibiting the enzyme's function.
Further, Myricetin is known to cause functional inhibition of various enzymes, possibly by inducing conformational changes in Galactose Mutarotase or blocking its active site, which would halt its enzymatic activity on galactose. Resveratrol directly binds to Galactose Mutarotase, interfering with its catalytic function. Similarly, Rutin, a glycoside derivative of quercetin, could inhibit the enzyme by attaching to it and preventing its action on galactose. Silybin from milk thistle may also bind to and inhibit Galactose Mutarotase, disrupting its normal enzymatic process. Tannic acid, with its protein-binding properties, acts by attaching to Galactose Mutarotase, which results in the inhibition of its activity on galactose. Troglitazone, a thiazolidinedione, can interact with Galactose Mutarotase, potentially altering the enzyme's conformation. Genistein, an isoflavone that inhibits tyrosine kinases, can indirectly affect the phosphorylation state of Galactose Mutarotase, thereby impacting its enzymatic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin is a dihydrochalcone, a type of natural phenol. It inhibits various glucose transporters which can influence glycolytic pathways and energy production mechanisms. Since Galactose Mutarotase is involved in the proper functioning of galactose metabolism, inhibiting glucose transport can decrease the substrate availability for the enzyme, thus functionally inhibiting its activity by reducing its interaction with its substrate. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonol, a subclass of flavonoids. As a broad-spectrum inhibitor of many enzymes, it can bind to the active sites or allosteric sites of enzymes, including those involved in carbohydrate metabolism. By this action, quercetin can inhibit the function of Galactose Mutarotase by preventing its interaction with galactose. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with various inhibitory effects on enzymes. It can inhibit enzymes by binding to their active sites, which in the case of Galactose Mutarotase could prevent the catalysis of galactose. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin is a flavonoid that exhibits inhibitory effects on numerous enzymes. By binding to Galactose Mutarotase, it can inhibit the enzyme’s ability to interact with galactose, thereby functionally inhibiting its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that can inhibit tyrosine kinases. Since phosphorylation can regulate enzyme activity, inhibition of tyrosine kinases can indirectly lead to reduced activity of Galactose Mutarotase by altering its phosphorylation state and thus its function. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is a natural flavonol which can inhibit a variety of enzymes within metabolic pathways. It can compete with the substrate or bind to other sites on Galactose Mutarotase, inhibiting the enzyme’s function. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $97.00 $188.00 $260.00 $510.00 $1022.00 | 3 | |
Myricetin is a flavonoid known to inhibit various enzymes. Its interaction with Galactose Mutarotase can result in the functional inhibition of the enzyme by blocking the active site or causing conformational changes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a stilbenoid and an inhibitor of several enzymes. It can inhibit the function of Galactose Mutarotase by binding to the enzyme, thus interfering with its capacity to catalyze the conversion of galactose. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $57.00 $72.00 $126.00 | 7 | |
Rutin, a glycoside of the flavonol quercetin, can have inhibitory effects on carbohydrate metabolizing enzymes. It may inhibit Galactose Mutarotase by binding to the enzyme and preventing its normal action on galactose. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silybin is a flavonolignan from milk thistle, known to inhibit various enzymes. By binding to Galactose Mutarotase, silybin can inhibit the enzyme's function and interaction with galactose. | ||||||